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Review article

Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature

Fedra Ciccarelli ; Allergy and Clinical Immunology Unit, Department of Life, Health, & Environmental Sciences, University of L’Aquila, Italy
Massimo De Martinis ; Università degli Studi de L'Aquila, Italia
Maria Maddalena Sirufo ; Allergy and Clinical Immunology Unit, Department of Life, Health, & Environmental Sciences, University of L’Aquila, Italy
Lia Ginaldi ; Allergy and Clinical Immunology Unit, Department of Life, Health, & Environmental Sciences, University of L’Aquila, Italy

Fulltext: english, PDF (119 KB) pages 169-169 downloads: 397* cite
APA 6th Edition
Ciccarelli, F., De Martinis, M., Sirufo, M.M. & Ginaldi, L. (2016). Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature. Acta Dermatovenerologica Croatica, 24 (3), 169-169. Retrieved from https://hrcak.srce.hr/165611
MLA 8th Edition
Ciccarelli, Fedra, et al. "Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature." Acta Dermatovenerologica Croatica, vol. 24, no. 3, 2016, pp. 169-169. https://hrcak.srce.hr/165611. Accessed 6 Dec. 2021.
Chicago 17th Edition
Ciccarelli, Fedra, Massimo De Martinis, Maria Maddalena Sirufo and Lia Ginaldi. "Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature." Acta Dermatovenerologica Croatica 24, no. 3 (2016): 169-169. https://hrcak.srce.hr/165611
Harvard
Ciccarelli, F., et al. (2016). 'Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature', Acta Dermatovenerologica Croatica, 24(3), pp. 169-169. Available at: https://hrcak.srce.hr/165611 (Accessed 06 December 2021)
Vancouver
Ciccarelli F, De Martinis M, Sirufo MM, Ginaldi L. Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature. Acta Dermatovenerol Croat. [Internet]. 2016 [cited 2021 December 06];24(3):169-169. Available from: https://hrcak.srce.hr/165611
IEEE
F. Ciccarelli, M. De Martinis, M.M. Sirufo and L. Ginaldi, "Psoriasis Induced by Anti-Tumor Necrosis Factor Alpha Agents: A Comprehensive Review of the Literature", Acta Dermatovenerologica Croatica, vol.24, no. 3, pp. 169-169, 2016. [Online]. Available: https://hrcak.srce.hr/165611. [Accessed: 06 December 2021]

Abstracts

Tumor necrosis factor alpha inhibitors revolutionized the management of patients affected by autoimmune diseases such as inflammatory bowel diseases, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis. The biologic agents targeted to blockade TNF-a, like infliximab, adalimumab, certulizumab pegol, etanercept and golimumab have a good safety profile however, with increasing , broader and prolonged use, could expose to an increased risk of adverse reactions included a wide spectrum of dermatological conditions of different etiology and morphology. Among these, of particular interest the development of skin immune-mediated diseases that seem to be the consequence of the paradoxical inflammation induced by anti-TNF-a therapy. The majority of these lesions are identified as psoriasiform with three main morphologies and different frequency: pustular psoriasis, signs of psoriasis and guttate, although among others, with less frequency erythrodermic or inverted psoriasis may be observed.

The increased incidence of these dermatological immune-mediated lesions highlight the importance of the skin as a main target of the side effect of anti-TNFa agents, while the immunopathogenetic hypothesis of these paradoxical effects are quite intriguing.

The aim of this review is to collect and to analyse  existing knowledge to better understand the pathogenetic mechanism of these complications  and suggest new fields of investigation,  to improve therapeutic strategies of autoimmune diseases and prevent and / or better address such complication.

Hrčak ID: 165611

URI
https://hrcak.srce.hr/165611

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