Izvorni znanstveni članak
https://doi.org/10.5599/jese.350
Simultaneous electrochemical determination of acetaminophen and metoclopramide at electrochemically pre-treated disposable graphite pencil electrode
Shreekant M. Patil
; P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003, India
Vijay P. Pattar
; P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003, India
Sharanappa T. Nandibewoor
; P. G. Department of Studies in Chemistry, Karnatak University, Dharwad 580003, India
Sažetak
A sensitive and economic voltammetric method was developed for the simultaneous determination of acetaminophen (AMP) and metoclopramide (MCP) using pre-treated graphite pencil electrode (PTGPE). Compared to a graphite pencil electrode, the pre-treated electrode showed an apparent shift of the oxidation potentials in the positive direction and a notable enhancement in the current responses for both AMP and MCP. Cyclic voltammetry (CV) was used to study the voltammetric behavior of the drugs, while differential pulse voltammetry (DPV) was used to determine AMP and MCP simulta-neously. The dependence of the current on scan rate, pH and concentration was investi-gated to boost the experimental conditions for simultaneous determination. The calibra-tion curves were obtained over the range of 0.1×10-7 to 1.1×10-7 M, the concentration of each of both the drugs was varied by keeping the other constant, and achieved lower detection limit of 3.25 nM for AMP and 1.16 nM for MCP. The developed method was found to be selective, and rapid for the simultaneous determination of AMP and MCP. The proposed method was applied simultaneously in real samples and pharmaceutical samples, with satisfactory results.
Ključne riječi
Acetaminophen; metoclopramide; voltammetry; graphite pencil electrode; analytical applications
Hrčak ID:
167040
URI
Datum izdavanja:
30.9.2016.
Posjeta: 1.115 *