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https://doi.org/10.5562/cca2992

Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate

Veronika Kovač   ORCID icon orcid.org/0000-0001-9538-6724 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Ivana Kmetič   ORCID icon orcid.org/0000-0001-5412-7128 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Teuta Murati ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Marina Miletić ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia
Lidija Barišić   ORCID icon orcid.org/0000-0003-3628-7501 ; Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR-10000 Zagreb, Croatia

Puni tekst: engleski, pdf (1011 KB) str. 339-343 preuzimanja: 513* citiraj
APA 6th Edition
Kovač, V., Kmetič, I., Murati, T., Miletić, M. i Barišić, L. (2016). Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate. Croatica Chemica Acta, 89 (3), 339-343. https://doi.org/10.5562/cca2992
MLA 8th Edition
Kovač, Veronika, et al. "Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate." Croatica Chemica Acta, vol. 89, br. 3, 2016, str. 339-343. https://doi.org/10.5562/cca2992. Citirano 23.02.2020.
Chicago 17th Edition
Kovač, Veronika, Ivana Kmetič, Teuta Murati, Marina Miletić i Lidija Barišić. "Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate." Croatica Chemica Acta 89, br. 3 (2016): 339-343. https://doi.org/10.5562/cca2992
Harvard
Kovač, V., et al. (2016). 'Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate', Croatica Chemica Acta, 89(3), str. 339-343. https://doi.org/10.5562/cca2992
Vancouver
Kovač V, Kmetič I, Murati T, Miletić M, Barišić L. Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate. Croatica Chemica Acta [Internet]. 2016 [pristupljeno 23.02.2020.];89(3):339-343. https://doi.org/10.5562/cca2992
IEEE
V. Kovač, I. Kmetič, T. Murati, M. Miletić i L. Barišić, "Facile Synthesis and Cytotoxic Activity of the First Ferrocene-Resveratrol Conjugate", Croatica Chemica Acta, vol.89, br. 3, str. 339-343, 2016. [Online]. https://doi.org/10.5562/cca2992

Sažetak
The bioorganometallic III containing trimethylene chain between ferrocene and resveratrol (3,5,4'-trihydroxystilbene, RSV) moieties connected via ester bond has been synthesized. The novel bioconjugate was characterized using IR and NMR (1H, 13C, COSY, NOESY, HMBC) spectroscopy, ESI-MS and HRMS. The RSV and ferrocene-RSV conjugate III were screened in vitro for their inhibitory effects against proliferation of hepatoblastoma (Hep G2) cells by MTT assay. Also, possible cytotoxicity towards normal ovary cells (CHO-K1) was evaluated. The obtained data revealed profound effects in biological/cytotoxic activity of III vs. RSV in Hep G2 cell line. Lower cytotoxicity of III was observed in normal ovary cells as compared to hepatoblastoma cells.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
ferrocene; ferrocene-resveratrol conjugate; hepatoblastoma; normal ovary cells; resveratrol

Hrčak ID: 169468

URI
https://hrcak.srce.hr/169468

Posjeta: 726 *