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https://doi.org/10.1515/aiht-2016-67-2882

Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation

Ranko Stojković ; Ruđer Bošković Institute, Zagreb, Croatia
Aleksandra Fučić ; Institute for Medical Research and Occubotional Health, Zagreb, Croatia
Dušica Ivanković ; Ruđer Bošković Institute, Zagreb, Croatia
Zoran Jukić ; General Hospital “Nova Gradiška”, Nova Gradiška, Croatia
Petra Radulović ; Clinical Hospital Centre “Sestre Milosrdnice”, Zagreb, Croatia
Josip Grah ; University Hospital “Zagreb”, Zagreb, Croatia
Nenad Kovačević ; University Hospital “Zagreb”, Zagreb, Croatia
Lovro Barišić ; University Hospital “Zagreb”, Zagreb, Croatia
Božo Krušlin ; Clinical Hospital Centre “Sestre Milosrdnice”, Zagreb, Croatia

Puni tekst: engleski, pdf (270 KB) str. 297-303 preuzimanja: 233* citiraj
APA 6th Edition
Stojković, R., Fučić, A., Ivanković, D., Jukić, Z., Radulović, P., Grah, J., ... Krušlin, B. (2016). Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation. Arhiv za higijenu rada i toksikologiju, 67 (4), 297-303. https://doi.org/10.1515/aiht-2016-67-2882
MLA 8th Edition
Stojković, Ranko, et al. "Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation." Arhiv za higijenu rada i toksikologiju, vol. 67, br. 4, 2016, str. 297-303. https://doi.org/10.1515/aiht-2016-67-2882. Citirano 13.11.2019.
Chicago 17th Edition
Stojković, Ranko, Aleksandra Fučić, Dušica Ivanković, Zoran Jukić, Petra Radulović, Josip Grah, Nenad Kovačević, Lovro Barišić i Božo Krušlin. "Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation." Arhiv za higijenu rada i toksikologiju 67, br. 4 (2016): 297-303. https://doi.org/10.1515/aiht-2016-67-2882
Harvard
Stojković, R., et al. (2016). 'Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation', Arhiv za higijenu rada i toksikologiju, 67(4), str. 297-303. https://doi.org/10.1515/aiht-2016-67-2882
Vancouver
Stojković R, Fučić A, Ivanković D, Jukić Z, Radulović P, Grah J i sur. Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation. Arh Hig Rada Toksikol. [Internet]. 2016 [pristupljeno 13.11.2019.];67(4):297-303. https://doi.org/10.1515/aiht-2016-67-2882
IEEE
R. Stojković, et al., "Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation", Arhiv za higijenu rada i toksikologiju, vol.67, br. 4, str. 297-303, 2016. [Online]. https://doi.org/10.1515/aiht-2016-67-2882

Sažetak
The mechanisms that lead to sex and age differences in biological responses to exposure to ionising radiation and related health risks have still not been investigated to a satisfactory extent. The significance of sex hormones in the aetiology of radiogenic cancer types requires a better understanding of the mechanisms involved, especially during organism development. The aim of this study was to show age and sex differences in genome damage between prepubertal and adult mice after single exposure to gamma radiation. Genome damage was measured 24 h, 48 h, and 72 h after exposure of 3-week and 12-week old BALB/CJ mice to 8 Gy of gamma radiation using an in vivo micronucleus assay. There was a significantly higher genome damage in prepubertal than in adult animals of both sexes for all sampling times. Irradiation caused a higher frequency of micronuclei in males of both age groups. Our study confirms sex differences in the susceptibility to effects of ionising radiation in mice and is the first to show that such a difference occurs already at prepubertal age.

Ključne riječi
gamma radiation; micronucleus; oestrogen; radiosensitivity; testosterone

Hrčak ID: 170511

URI
https://hrcak.srce.hr/170511

[hrvatski]

Posjeta: 393 *