APA 6th Edition Bedenić, B., Sardelić, S., Vranić-Ladavac, M., Barišić, N. i Ladavac, R. (2014). KARBAPENEMAZE GRAM-NEGATIVNIH BAKTERIJA. Liječnički vjesnik, 136 (3-4), 0-0. Preuzeto s https://hrcak.srce.hr/172597
MLA 8th Edition Bedenić, Branka, et al. "KARBAPENEMAZE GRAM-NEGATIVNIH BAKTERIJA." Liječnički vjesnik, vol. 136, br. 3-4, 2014, str. 0-0. https://hrcak.srce.hr/172597. Citirano 24.01.2020.
Chicago 17th Edition Bedenić, Branka, Sanda Sardelić, Mirna Vranić-Ladavac, Nada Barišić i Ranko Ladavac. "KARBAPENEMAZE GRAM-NEGATIVNIH BAKTERIJA." Liječnički vjesnik 136, br. 3-4 (2014): 0-0. https://hrcak.srce.hr/172597
Harvard Bedenić, B., et al. (2014). 'KARBAPENEMAZE GRAM-NEGATIVNIH BAKTERIJA', Liječnički vjesnik, 136(3-4), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172597 (Datum pristupa: 24.01.2020.)
Vancouver Bedenić B, Sardelić S, Vranić-Ladavac M, Barišić N, Ladavac R. KARBAPENEMAZE GRAM-NEGATIVNIH BAKTERIJA. Liječnički vjesnik [Internet]. 2014 [pristupljeno 24.01.2020.];136(3-4):0-0. Dostupno na: https://hrcak.srce.hr/172597
IEEE B. Bedenić, S. Sardelić, M. Vranić-Ladavac, N. Barišić i R. Ladavac, "KARBAPENEMAZE GRAM-NEGATIVNIH BAKTERIJA", Liječnički vjesnik, vol.136, br. 3-4, str. 0-0, 2014. [Online]. Dostupno na: https://hrcak.srce.hr/172597. [Citirano: 24.01.2020.]
Sažetak Carbapenems are often antibiotics of last resort for the treatment of severe infections. They are stable to most b-lactamases produced by gram-negative bacteria. However, bacterial enzymes named carbapenemases can efficiently hydrolyze carbapenems. They are produced most frequently by Enterobacteriaceae and non-fermentative bacteria such as Pseudomonas aeruginosa and Acinetobacterbaumannnii. They belong to group A (KPC, SME, IMI, NMC), B (VIM, IMP, SPM, GIM, NDM, SIM, DIM, AIM) and D (OXA-23, OXA-24, OXA-48, OXA-58, OXA-143). The accurate and rapid laboratory identification of carbapenem-resistant isolates is important to prevent spread of such multidrug resistant strains and to avoid therapeutic failures. Therapeutic options are often limited because carbapenemases are encoded on mobile genetic elements which often harbour resistance genes to other groups of antibiotics. Thus, colistin is often the only therapeutic option.