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AUTOLOGOUS STEM CELL TRANSPLANTATION IN REFRACTORY OR RELAPSED DIFFUSE LARGE B CELL LYMPHOMA – A SINGLE CENTRE EXPERIENCE

Vibor Milunović
Martina Bogeljić Patekar
Vinko Roso
Viktor Zatezalo
Bojana Aćamović Stipinović
Karla Mišura Jakobac
Njetočka Gredelj Šimec
Delfa Radić-Krišto
Ana Planinc-Peraica
Slobodanka Ostojić Kolonić

Puni tekst: hrvatski, pdf (1 MB) str. 0-0 preuzimanja: 224* citiraj
APA 6th Edition
Milunović, V., Bogeljić Patekar, M., Roso, V., Zatezalo, V., Aćamović Stipinović, B., Mišura Jakobac, K., ... Ostojić Kolonić, S. (2015). AUTOLOGNA TRANSPLANTACIJA PERIFERNIH MATIČNIH STANICA U REFRAKTORNOM ILI RELAPSNOM NE-HODGKINOVU LIMFOMU DIFUZNOGA B-VELIKOSTANIČNOG TIPA – ISKUSTVO JEDNOG CENTRA. Liječnički vjesnik, 137 (9-10), 0-0. Preuzeto s https://hrcak.srce.hr/172718
MLA 8th Edition
Milunović, Vibor, et al. "AUTOLOGNA TRANSPLANTACIJA PERIFERNIH MATIČNIH STANICA U REFRAKTORNOM ILI RELAPSNOM NE-HODGKINOVU LIMFOMU DIFUZNOGA B-VELIKOSTANIČNOG TIPA – ISKUSTVO JEDNOG CENTRA." Liječnički vjesnik, vol. 137, br. 9-10, 2015, str. 0-0. https://hrcak.srce.hr/172718. Citirano 16.10.2019.
Chicago 17th Edition
Milunović, Vibor, Martina Bogeljić Patekar, Vinko Roso, Viktor Zatezalo, Bojana Aćamović Stipinović, Karla Mišura Jakobac, Njetočka Gredelj Šimec, Delfa Radić-Krišto, Ana Planinc-Peraica i Slobodanka Ostojić Kolonić. "AUTOLOGNA TRANSPLANTACIJA PERIFERNIH MATIČNIH STANICA U REFRAKTORNOM ILI RELAPSNOM NE-HODGKINOVU LIMFOMU DIFUZNOGA B-VELIKOSTANIČNOG TIPA – ISKUSTVO JEDNOG CENTRA." Liječnički vjesnik 137, br. 9-10 (2015): 0-0. https://hrcak.srce.hr/172718
Harvard
Milunović, V., et al. (2015). 'AUTOLOGNA TRANSPLANTACIJA PERIFERNIH MATIČNIH STANICA U REFRAKTORNOM ILI RELAPSNOM NE-HODGKINOVU LIMFOMU DIFUZNOGA B-VELIKOSTANIČNOG TIPA – ISKUSTVO JEDNOG CENTRA', Liječnički vjesnik, 137(9-10), str. 0-0. Preuzeto s: https://hrcak.srce.hr/172718 (Datum pristupa: 16.10.2019.)
Vancouver
Milunović V, Bogeljić Patekar M, Roso V, Zatezalo V, Aćamović Stipinović B, Mišura Jakobac K i sur. AUTOLOGNA TRANSPLANTACIJA PERIFERNIH MATIČNIH STANICA U REFRAKTORNOM ILI RELAPSNOM NE-HODGKINOVU LIMFOMU DIFUZNOGA B-VELIKOSTANIČNOG TIPA – ISKUSTVO JEDNOG CENTRA. Liječnički vjesnik [Internet]. 2015 [pristupljeno 16.10.2019.];137(9-10):0-0. Dostupno na: https://hrcak.srce.hr/172718
IEEE
V. Milunović, et al., "AUTOLOGNA TRANSPLANTACIJA PERIFERNIH MATIČNIH STANICA U REFRAKTORNOM ILI RELAPSNOM NE-HODGKINOVU LIMFOMU DIFUZNOGA B-VELIKOSTANIČNOG TIPA – ISKUSTVO JEDNOG CENTRA", Liječnički vjesnik, vol.137, br. 9-10, str. 0-0, 2015. [Online]. Dostupno na: https://hrcak.srce.hr/172718. [Citirano: 16.10.2019.]

Sažetak
Autologous stem cell transplantation represents the gold standard in chemosensitive diffuse B large cell lymphoma in relapse or in refractory setting. The aim of this study was to present the outcome of peripheral autologous stem cell transplantation in patients with refractory or relapsed diffuse large B cell lymphoma. We retrospectively analysed the data of 62 patients, who underwent this procedure for the period 2000–2013. The majority of patients (71%) were treated with miniBEAM salvage chemotherapy and all received BEAM myeloablative protocol followed by the stem cell reinfusion. The overall response rate for autologous transplantation was 75.8%. Median overall survival was 37.2 months. Median event-free survival was 16.9 months. Factors associated with overall survival were state of disease prior to salvage chemotherapy, chemosensitivity of disease, International prognostic index, disease activity at the relapse, response to autologous transplantation and post-transplantation radiotherapy. The use of rituximab was not significantly correlated to the outcome. In this patient group autologous stem cell transplantation was found to be effective in achieving remission and survival showing the adequate role of this procedure in this clinical setting. We stress out that autologous stem cell transplantation was effective in 32.5% patients with chemorefractory disease after salvage therapy.

Ključne riječi
Lymphoma, large B-cell, diffuse – therapy; Hematopoietic stem cell transplantation; Transplantation, autologous; Antineoplastic combined chemotherapy protocols – therapeutic use; Antibodies, monoclonal, murinederived – therapeutic use; Salvage therapy; Recurrence; Survival analysis; Prognosis; Retrospective studies

Hrčak ID: 172718

URI
https://hrcak.srce.hr/172718

[hrvatski]

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