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Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study

Rania Abdel Hay ; Cairo University, Egypt
Mostafa Abou El-Ela
Eman Shaarawy
Mohamed El-Komy
Marwa Fawzy
Rehab Hegazy
Amin Sharobim
Nadine Moustafa
Laila Rashed
Khalda Sayed Amr

Puni tekst: engleski, PDF (163 KB) str. 282-282 preuzimanja: 317* citiraj
APA 6th Edition
Abdel Hay, R., Abou El-Ela, M., Shaarawy, E., El-Komy, M., Fawzy, M., Hegazy, R., ... Sayed Amr, K. (2016). Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study. Acta Dermatovenerologica Croatica, 24 (4), 282-282. Preuzeto s https://hrcak.srce.hr/173947
MLA 8th Edition
Abdel Hay, Rania, et al. "Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study." Acta Dermatovenerologica Croatica, vol. 24, br. 4, 2016, str. 282-282. https://hrcak.srce.hr/173947. Citirano 17.10.2021.
Chicago 17th Edition
Abdel Hay, Rania, Mostafa Abou El-Ela, Eman Shaarawy, Mohamed El-Komy, Marwa Fawzy, Rehab Hegazy, Amin Sharobim, Nadine Moustafa, Laila Rashed i Khalda Sayed Amr. "Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study." Acta Dermatovenerologica Croatica 24, br. 4 (2016): 282-282. https://hrcak.srce.hr/173947
Harvard
Abdel Hay, R., et al. (2016). 'Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study', Acta Dermatovenerologica Croatica, 24(4), str. 282-282. Preuzeto s: https://hrcak.srce.hr/173947 (Datum pristupa: 17.10.2021.)
Vancouver
Abdel Hay R, Abou El-Ela M, Shaarawy E, El-Komy M, Fawzy M, Hegazy R i sur. Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study. Acta Dermatovenerol Croat. [Internet]. 2016 [pristupljeno 17.10.2021.];24(4):282-282. Dostupno na: https://hrcak.srce.hr/173947
IEEE
R. Abdel Hay, et al., "Is there a Link between Human Herpes Virus Infection and Toll-like Receptors in the Pathogenesis of Pityriasis Rosea? A Case-control Study", Acta Dermatovenerologica Croatica, vol.24, br. 4, str. 282-282, 2016. [Online]. Dostupno na: https://hrcak.srce.hr/173947. [Citirano: 17.10.2021.]

Sažetak

Human herpesvirus (HHV) 6 and 7 are involved in the pathogenesis of pityriasis rosea (PR). Our aim was to evaluate the role of the innate immune response in PR through the detection of Toll-like receptors (TLR) 2, 3, 4, 7, 8, and 9 expression in the skin of affected patients and to detect the possibility of being induced by HHV-6 and/or HHV-7 viral coexistence in these patients. Twenty-four patients with PR and 24 healthy controls were included in this case-control study. Biopsy was obtained from the PR lesion and from the healthy skin of controls for detection of HHV-6 and 7 as well as TLRs 2, 3, 4, 7, 8, and 9 gene expression using real-time polymerase chain reaction (PCR). Significantly elevated expression of all studied TLRs and significantly higher viral load of HHV-6 and 7 in PR cases were detected. A significant higher expression of TLR2 and 4 in HHV-7 positive cases and a significant positive correlation between TLR9 and HHV-7 viral load were documented. HHV6 and 7 may also be involved in the pathogenesis of PR via TLR pathways

 

Ključne riječi
innate immunity; pattern recognition receptors; RT-PCR; viral coexistence; viral reactivation

Hrčak ID: 173947

URI
https://hrcak.srce.hr/173947

Posjeta: 554 *