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Acta Pharmaceutica, Vol. 54 No. 2, 2004.

Izvorni znanstveni članak

Lipophilicity study of salicylamide

MARICA MEDIĆ-SARIĆ
ANA MORNAR
IVONA JASPRICA

Puni tekst: engleski, pdf (95 KB) str. 91-101 preuzimanja: 781* citiraj
APA 6th Edition
MEDIĆ-SARIĆ, M., MORNAR, A. i JASPRICA, I. (2004). Lipophilicity study of salicylamide. Acta Pharmaceutica, 54 (2), 91-101. Preuzeto s https://hrcak.srce.hr/16795
MLA 8th Edition
MEDIĆ-SARIĆ, MARICA, et al. "Lipophilicity study of salicylamide." Acta Pharmaceutica, vol. 54, br. 2, 2004, str. 91-101. https://hrcak.srce.hr/16795. Citirano 23.05.2019.
Chicago 17th Edition
MEDIĆ-SARIĆ, MARICA, ANA MORNAR i IVONA JASPRICA. "Lipophilicity study of salicylamide." Acta Pharmaceutica 54, br. 2 (2004): 91-101. https://hrcak.srce.hr/16795
Harvard
MEDIĆ-SARIĆ, M., MORNAR, A., i JASPRICA, I. (2004). 'Lipophilicity study of salicylamide', Acta Pharmaceutica, 54(2), str. 91-101. Preuzeto s: https://hrcak.srce.hr/16795 (Datum pristupa: 23.05.2019.)
Vancouver
MEDIĆ-SARIĆ M, MORNAR A, JASPRICA I. Lipophilicity study of salicylamide. Acta Pharm. [Internet]. 2004 [pristupljeno 23.05.2019.];54(2):91-101. Dostupno na: https://hrcak.srce.hr/16795
IEEE
M. MEDIĆ-SARIĆ, A. MORNAR i I. JASPRICA, "Lipophilicity study of salicylamide", Acta Pharmaceutica, vol.54, br. 2, str. 91-101, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/16795. [Citirano: 23.05.2019.]

Sažetak
Molecular lipophilicity was studied using salicylamide as a model drug. Log P value for the target compound was experimentally determined by the "shake-flask" method and calculated using nine different computer programs based on atom/fragment contributions, structural parameters, atom-type electrotopological-state indices and neural network modeling, and on topological structure descriptors. Our analysis demonstrates good agreement between the experimentally observed log P value of salicylamide and the value calculated by the CSLogP program, based on topological structure descriptors and electrotopological indices.

Ključne riječi
lipophilicity; salicylamide; log P; computer modeling

Hrčak ID: 16795

URI
https://hrcak.srce.hr/16795

[hrvatski]

Posjeta: 1.215 *