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Acta Pharmaceutica, Vol. 54 No. 4, 2004.

Izvorni znanstveni članak

Optimization of chitosan films as substitute of animal and human epidermal sheets for in vitro permeation of polar and non polar drugs

VIKAS RANA
KUMAR BABITA
DINESH GOYAL
RAKESH GOREA
ASHOK TIWARY

Puni tekst: engleski, pdf (148 KB) str. 287-299 preuzimanja: 440* citiraj
APA 6th Edition
RANA, V., BABITA, K., GOYAL, D., GOREA, R. i TIWARY, A. (2004). Optimization of chitosan films as substitute of animal and human epidermal sheets for in vitro permeation of polar and non polar drugs. Acta Pharmaceutica, 54 (4), 287-299. Preuzeto s https://hrcak.srce.hr/16905
MLA 8th Edition
RANA, VIKAS, et al. "Optimization of chitosan films as substitute of animal and human epidermal sheets for in vitro permeation of polar and non polar drugs." Acta Pharmaceutica, vol. 54, br. 4, 2004, str. 287-299. https://hrcak.srce.hr/16905. Citirano 24.05.2019.
Chicago 17th Edition
RANA, VIKAS, KUMAR BABITA, DINESH GOYAL, RAKESH GOREA i ASHOK TIWARY. "Optimization of chitosan films as substitute of animal and human epidermal sheets for in vitro permeation of polar and non polar drugs." Acta Pharmaceutica 54, br. 4 (2004): 287-299. https://hrcak.srce.hr/16905
Harvard
RANA, V., et al. (2004). 'Optimization of chitosan films as substitute of animal and human epidermal sheets for in vitro permeation of polar and non polar drugs', Acta Pharmaceutica, 54(4), str. 287-299. Preuzeto s: https://hrcak.srce.hr/16905 (Datum pristupa: 24.05.2019.)
Vancouver
RANA V, BABITA K, GOYAL D, GOREA R, TIWARY A. Optimization of chitosan films as substitute of animal and human epidermal sheets for in vitro permeation of polar and non polar drugs. Acta Pharm. [Internet]. 2004 [pristupljeno 24.05.2019.];54(4):287-299. Dostupno na: https://hrcak.srce.hr/16905
IEEE
V. RANA, K. BABITA, D. GOYAL, R. GOREA i A. TIWARY, "Optimization of chitosan films as substitute of animal and human epidermal sheets for in vitro permeation of polar and non polar drugs", Acta Pharmaceutica, vol.54, br. 4, str. 287-299, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/16905. [Citirano: 24.05.2019.]

Sažetak
The present investigation is aimed at preparing chitosan films capable of simulating the flux of modal drugs, 5-fluorouracil (5-FU) and indomethacin (INDO), across rat, rabbit and human cadaver epidermal sheets. Application of statistical design revealed that the concentration of chitosan, crosslinking time and concentration of crosslinking agent significantly influenced the in vitro flux of 5-FU and INDO across chitosan films. Multiple linear regression revealed a linear influence of all these active variables on 5-FU and INDO flux. It was deduced from atomic absorption spectroscopic analyses, DSC and IR spectroscopic data that 5% (m/V) sodium tripolyphosphate (NaTPP) produced optimum crosslinking of chitosan films. The in vitro permeation of both 5-FU and INDO across optimized film formulations was found to be comparable to that obtained across rat, rabbit and human epidermal sheets. These results indicate that optimized chitosan films have a potential to be developed as a substitute for animal and human cadaver epidermal sheets for preliminary in vitro permeation studies.

Ključne riječi
chitosan film formulations; sodium tripolyphosphate; rat epidermis; rabbit epidermis; human epidermis

Hrčak ID: 16905

URI
https://hrcak.srce.hr/16905

[hrvatski]

Posjeta: 749 *