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Acta Pharmaceutica, Vol. 54 No. 4, 2004.

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Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery

PARISA YOUNESSI
MOHAMMAD REZA AVADI
KOOROUSH SHAMIMI
ASSAL MIR MOHAMMAD SADEGHI
LEILA MOEZI ELAHEH NAHID
KHOSROW BAYATI
AHMAD REZA DEHPOUR
MORTEZA RAFIEE-TEHRANI

Puni tekst: engleski, pdf (90 KB) str. 339-345 preuzimanja: 538* citiraj
APA 6th Edition
YOUNESSI, P., AVADI, M.R., SHAMIMI, K., SADEGHI, A.M.M., MOEZI ELAHEH NAHID, L., BAYATI, K., ... RAFIEE-TEHRANI, M. (2004). Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery. Acta Pharmaceutica, 54 (4), 339-345. Preuzeto s https://hrcak.srce.hr/16909
MLA 8th Edition
YOUNESSI, PARISA, et al. "Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery." Acta Pharmaceutica, vol. 54, br. 4, 2004, str. 339-345. https://hrcak.srce.hr/16909. Citirano 17.02.2019.
Chicago 17th Edition
YOUNESSI, PARISA, MOHAMMAD REZA AVADI, KOOROUSH SHAMIMI, ASSAL MIR MOHAMMAD SADEGHI, LEILA MOEZI ELAHEH NAHID, KHOSROW BAYATI, AHMAD REZA DEHPOUR i MORTEZA RAFIEE-TEHRANI. "Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery." Acta Pharmaceutica 54, br. 4 (2004): 339-345. https://hrcak.srce.hr/16909
Harvard
YOUNESSI, P., et al. (2004). 'Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery', Acta Pharmaceutica, 54(4), str. 339-345. Preuzeto s: https://hrcak.srce.hr/16909 (Datum pristupa: 17.02.2019.)
Vancouver
YOUNESSI P, AVADI MR, SHAMIMI K, SADEGHI AMM, MOEZI ELAHEH NAHID L, BAYATI K i sur. Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery. Acta Pharm. [Internet]. 2004 [pristupljeno 17.02.2019.];54(4):339-345. Dostupno na: https://hrcak.srce.hr/16909
IEEE
P. YOUNESSI, et al., "Preparation and ex vivo evaluation of TEC as an absorption enhancer for poorly absorbable compounds in colon specific drug delivery", Acta Pharmaceutica, vol.54, br. 4, str. 339-345, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/16909. [Citirano: 17.02.2019.]

Sažetak
In previous studies, it was established that chitosan and its quaternized derivatives are potent enhancers of hydrophilic compounds absorption across intestinal epithelia. The aim of this study was to evaluate the application of a new quaternized chitosan, triethyl chitosan (TEC), in pharmaceutical approaches. TEC was synthesized by a one step process via a 22 factorial design to optimize the preparation conditions. In ex vivo experiments, everted rat colon sac was used to determine the effect of TEC on the penetration of hydrophilic compounds of different molecular masses (e.g., sodium fluorescein and brilliant blue) through colonic epithelia in comparison with chitosan at pH 7.4. These studies indicated a significant increase in absorption of sodium fluorescein and brilliant blue in the presence of TEC compared to chitosan. TEC bearing positive charge is able to interact with the tight junctions of colon epithelia and hence increase the permeation of sodium fluorescein and brilliant blue through the tight junctions. This investigation has shown that triethyl chitosan could be used as a penetration enhancer for poorly absorbable compounds in the colon drug delivery system.

Ključne riječi
triethyl chitosan; absorption enhancer; colon

Hrčak ID: 16909

URI
https://hrcak.srce.hr/16909

[hrvatski]

Posjeta: 863 *