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https://doi.org/10.20471/acc.2017.56.02.02

QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists

Denis Baričević   ORCID icon orcid.org/0000-0003-1648-1374 ; Jordanovac Clinical Department of Respiratory Diseases, Zagreb University Hospital Centre
Sanja Popović Grle   ORCID icon orcid.org/0000-0003-2513-9079 ; Jordanovac Clinical Department of Respiratory Diseases, Zagreb University Hospital Centre
Jadranka Morović Vergles ; Clinical Department of Internal Medicine, Dubrava University Hospital
Silvija Čuković Čavka ; Department of Gastroenterology, Clinical Department of Internal Medicine, Zagreb University Hospital Centre
Marko Jakopović   ORCID icon orcid.org/0000-0002-4815-7512 ; Jordanovac Clinical Department of Respiratory Diseases, Zagreb University Hospital Centre
Gzim Redžepi ; Jordanovac Clinical Department of Respiratory Diseases, Zagreb University Hospital Centre
Zagorka Boras ; Jordanovac Clinical Department of Respiratory Diseases, Zagreb University Hospital Centre
Marinka Baričević ; Dental Practice, Zagreb-West Health Center, Zagreb, Croatia
Miroslav Samaržija ; Jordanovac Clinical Department of Respiratory Diseases, Zagreb University Hospital Centre

Puni tekst: engleski, pdf (104 KB) str. 203-209 preuzimanja: 668* citiraj
APA 6th Edition
Baričević, D., Popović Grle, S., Morović Vergles, J., Čuković Čavka, S., Jakopović, M., Redžepi, G., ... Samaržija, M. (2017). QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists. Acta clinica Croatica, 56. (2.), 203-209. https://doi.org/10.20471/acc.2017.56.02.02
MLA 8th Edition
Baričević, Denis, et al. "QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists." Acta clinica Croatica, vol. 56., br. 2., 2017, str. 203-209. https://doi.org/10.20471/acc.2017.56.02.02. Citirano 24.06.2021.
Chicago 17th Edition
Baričević, Denis, Sanja Popović Grle, Jadranka Morović Vergles, Silvija Čuković Čavka, Marko Jakopović, Gzim Redžepi, Zagorka Boras, Marinka Baričević i Miroslav Samaržija. "QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists." Acta clinica Croatica 56., br. 2. (2017): 203-209. https://doi.org/10.20471/acc.2017.56.02.02
Harvard
Baričević, D., et al. (2017). 'QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists', Acta clinica Croatica, 56.(2.), str. 203-209. https://doi.org/10.20471/acc.2017.56.02.02
Vancouver
Baričević D, Popović Grle S, Morović Vergles J, Čuković Čavka S, Jakopović M, Redžepi G i sur. QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists. Acta clinica Croatica [Internet]. 2017 [pristupljeno 24.06.2021.];56.(2.):203-209. https://doi.org/10.20471/acc.2017.56.02.02
IEEE
D. Baričević, et al., "QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent Tuberculosis Infection in Arthritis Patients Treated with Tumor Necrosis Factor Antagonists", Acta clinica Croatica, vol.56., br. 2., str. 203-209, 2017. [Online]. https://doi.org/10.20471/acc.2017.56.02.02

Sažetak
The aim of this study was to investigate the role of the QuantiFERON-TB Gold In-Tube test (QFT-GIT) in detecting latent tuberculosis in immunocompromised patients before introducing tumor necrosis factor (TNF-α) antagonists. The study included 300 subjects of similar age. The study group comprised of 150 QuantiFERON (QFT) positive subjects with rheumatoid arthritis, Crohn’s disease, ulcerative colitis, ankylosing spondylitis and psoriatic arthritis, while control group comprised of 150 QFT negative respondents with the same diseases. Exhaustive medical history was documented for all patients. Screening tests were performed including QFT-GIT, tuberculin skin test (TST), chest radiography and detection of Mycobacterium tuberculosisin sputum culture 2 times. A positive QFT-GIT test result, regardless of TST result, was considered as an indication for latent tuberculosis infection (LTBI) treatment. Results of this study showed good correlation between the conclusive results of QFT-GIT and TST. All study group patients had normal clinical findings, normal radiologic findings and negative results of sputum microbiological analysis during the course of prophylaxis and after its completion and during the course of biological therapy. Conversion of positive QFT-GIT test to negative was observed in 4% of study group patients, while QFT negative respondents remained negative. There was a statistically significant positive correlation between QFTGIT, TST results and patient age, smoking habit and contact with tuberculosis. Study results showed that along with good clinical evaluation and detailed medical history, it is important to conduct testing in order to avoid disease progression or unnecessary isoniazid prophylaxis.

Ključne riječi
Tuberculin test; Latent tuberculosis – diagnosis; Arthritis; Tumor necrosis factors – antagonists and inhibitors; Biological therapy; Croatia

Hrčak ID: 186388

URI
https://hrcak.srce.hr/186388

[hrvatski]

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