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Protein-associated O-GIcNAc, a multifunctional mechanism in cell signaling and its role in the pathogenesis of diabetes, stress and malignant diseases

Tamas Nagy
Attila Miseta
Gabor L. Kovacs

Puni tekst: engleski, pdf (322 KB) str. 162-177 preuzimanja: 323* citiraj
APA 6th Edition
Nagy, T., Miseta, A. i Kovacs, G.L. (2007). Protein-associated O-GIcNAc, a multifunctional mechanism in cell signaling and its role in the pathogenesis of diabetes, stress and malignant diseases. Biochemia Medica, 17 (2), 162-177. Preuzeto s https://hrcak.srce.hr/18131
MLA 8th Edition
Nagy, Tamas, et al. "Protein-associated O-GIcNAc, a multifunctional mechanism in cell signaling and its role in the pathogenesis of diabetes, stress and malignant diseases." Biochemia Medica, vol. 17, br. 2, 2007, str. 162-177. https://hrcak.srce.hr/18131. Citirano 26.01.2021.
Chicago 17th Edition
Nagy, Tamas, Attila Miseta i Gabor L. Kovacs. "Protein-associated O-GIcNAc, a multifunctional mechanism in cell signaling and its role in the pathogenesis of diabetes, stress and malignant diseases." Biochemia Medica 17, br. 2 (2007): 162-177. https://hrcak.srce.hr/18131
Harvard
Nagy, T., Miseta, A., i Kovacs, G.L. (2007). 'Protein-associated O-GIcNAc, a multifunctional mechanism in cell signaling and its role in the pathogenesis of diabetes, stress and malignant diseases', Biochemia Medica, 17(2), str. 162-177. Preuzeto s: https://hrcak.srce.hr/18131 (Datum pristupa: 26.01.2021.)
Vancouver
Nagy T, Miseta A, Kovacs GL. Protein-associated O-GIcNAc, a multifunctional mechanism in cell signaling and its role in the pathogenesis of diabetes, stress and malignant diseases. Biochemia Medica [Internet]. 2007 [pristupljeno 26.01.2021.];17(2):162-177. Dostupno na: https://hrcak.srce.hr/18131
IEEE
T. Nagy, A. Miseta i G.L. Kovacs, "Protein-associated O-GIcNAc, a multifunctional mechanism in cell signaling and its role in the pathogenesis of diabetes, stress and malignant diseases", Biochemia Medica, vol.17, br. 2, str. 162-177, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/18131. [Citirano: 26.01.2021.]
Puni tekst: hrvatski, pdf (322 KB) str. 162-177 preuzimanja: 383* citiraj
APA 6th Edition
Nagy, T., Miseta, A. i Kovacs, G.L. (2007). O-GIcNAc, proteinski vezan višefunkcijski mehanizam u staničnoj signalizaciji te njegova uloga u patogenezi šećerne bolesti, stresa i zloćudnih bolesti. Biochemia Medica, 17 (2), 162-177. Preuzeto s https://hrcak.srce.hr/18131
MLA 8th Edition
Nagy, Tamas, et al. "O-GIcNAc, proteinski vezan višefunkcijski mehanizam u staničnoj signalizaciji te njegova uloga u patogenezi šećerne bolesti, stresa i zloćudnih bolesti." Biochemia Medica, vol. 17, br. 2, 2007, str. 162-177. https://hrcak.srce.hr/18131. Citirano 26.01.2021.
Chicago 17th Edition
Nagy, Tamas, Attila Miseta i Gabor L. Kovacs. "O-GIcNAc, proteinski vezan višefunkcijski mehanizam u staničnoj signalizaciji te njegova uloga u patogenezi šećerne bolesti, stresa i zloćudnih bolesti." Biochemia Medica 17, br. 2 (2007): 162-177. https://hrcak.srce.hr/18131
Harvard
Nagy, T., Miseta, A., i Kovacs, G.L. (2007). 'O-GIcNAc, proteinski vezan višefunkcijski mehanizam u staničnoj signalizaciji te njegova uloga u patogenezi šećerne bolesti, stresa i zloćudnih bolesti', Biochemia Medica, 17(2), str. 162-177. Preuzeto s: https://hrcak.srce.hr/18131 (Datum pristupa: 26.01.2021.)
Vancouver
Nagy T, Miseta A, Kovacs GL. O-GIcNAc, proteinski vezan višefunkcijski mehanizam u staničnoj signalizaciji te njegova uloga u patogenezi šećerne bolesti, stresa i zloćudnih bolesti. Biochemia Medica [Internet]. 2007 [pristupljeno 26.01.2021.];17(2):162-177. Dostupno na: https://hrcak.srce.hr/18131
IEEE
T. Nagy, A. Miseta i G.L. Kovacs, "O-GIcNAc, proteinski vezan višefunkcijski mehanizam u staničnoj signalizaciji te njegova uloga u patogenezi šećerne bolesti, stresa i zloćudnih bolesti", Biochemia Medica, vol.17, br. 2, str. 162-177, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/18131. [Citirano: 26.01.2021.]

Sažetak
Growing evidence suggests that hexosamine biosynthesis pathway (HBP) plays a significant role in the modulation of intracellular signaling transduc-tion pathways. Its end product, UDP-GlcNAc is a substrate for the addition of O-linked β-N-acetylglucosamine (O-GlcNAc) to Ser/Thr residues. This process regulates a wide range of proteins usually by interfering with phosphoryla-tion. O-GlcNAc is a dynamic posttranslational modification, which is essential in normal mammalian cellular function; however, its main significance has been revealed in pathological processes. Since HBP requires glucose, high glucose intake considerably increases the flux through HBP and also increases the ratio of O-GlcNAc-associated proteins. This has an impact on various cellular functions, involving either the traditionally recognized detrimental effects in diabetes and diabetic complications or, as found recently, O-GlcNAc might be beneficial in ischemia/reperfusion injuries. In this review we summarize the current findings in O-GlcNAc research concerning its participation in signaling pathways and cellular processes. We also focus on the impact of O-GlcNAc in diseases such as diabetes, inflammation, development of malignancies or hypoxia-induced injuries.

Ključne riječi
O-GlcNAc; Ca2+; diabetes; stress response; malignancy

Hrčak ID: 18131

URI
https://hrcak.srce.hr/18131

[hrvatski]

Posjeta: 1.031 *