Izvorni znanstveni članak

https://doi.org/10.2478/acph-2018-0017

Development and evaluation of orally disintegrating tablet containing mosapride resin complex

TONG WU ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
GUANHUA WANG ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
CAIHONG SHI ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
JINGHAN LI ; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,Liaoning Province, P.R. China
NA ZHAO ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
ZIHAO DONG ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China
WEISAN PAN ; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016,Liaoning Province, P.R. China
XIANGRONG ZHANG ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China; State Key Laboratory of Medicinal Resources, Chemistry and Molecular Engineering, Guangxi Normal University, Gui Lin 541006, P.R. China

Sažetak

The purpose of this study was to prepare a mosapride citrate-resin (Amberlite® IRP 88) complex and orally fast-disintegrating tablets of the resin complex. The resinate complex of mosapride-Amberlite® IRP 88, weight ratio 2:1, was prepared in an ethanol-water solution. The effects of alcohol concentration, temperature, and pH of the solution on complex formation were evaluated. The complex physicochemical properties were characterized by differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Orally disintegrating tablets were prepared by direct compression and were optimized using the response surface method. Optimized orally fast-disintegrating tablets disintegrated within 18 s. The pH dependence of mosapride release from the tablet decreased drug dissolution in simulated saliva, whereas it promptly released in the pH 1.0 solution. The data reported herein clearly demonstrate that tablets containing the mosapride- Amberlite® IRP 88 complex for oral disintegration could be particularly useful for patients with swallowing difficulties.

Ključne riječi

Mosapride citrate; Amberlite®IRP 88 resin; resin complex; orally disintegrating tablet; physicochemical characterization; dissolution

Hrčak ID:

193570

URI

https://hrcak.srce.hr/193570

Datum izdavanja:

30.6.2018.

Posjeta: 1.620 *