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Arhiv za higijenu rada i toksikologiju, Vol. 56 No. 2, 2005.

Stručni rad

Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?

Simona Bussi
Alberto Morisetti

Puni tekst: engleski, pdf (73 KB) str. 157-160 preuzimanja: 1.890* citiraj
APA 6th Edition
Bussi, S. i Morisetti, A. (2005). Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arhiv za higijenu rada i toksikologiju, 56 (2), 157-160. Preuzeto s https://hrcak.srce.hr/144
MLA 8th Edition
Bussi, Simona i Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju, vol. 56, br. 2, 2005, str. 157-160. https://hrcak.srce.hr/144. Citirano 21.02.2019.
Chicago 17th Edition
Bussi, Simona i Alberto Morisetti. "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?." Arhiv za higijenu rada i toksikologiju 56, br. 2 (2005): 157-160. https://hrcak.srce.hr/144
Harvard
Bussi, S., i Morisetti, A. (2005). 'Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?', Arhiv za higijenu rada i toksikologiju, 56(2), str. 157-160. Preuzeto s: https://hrcak.srce.hr/144 (Datum pristupa: 21.02.2019.)
Vancouver
Bussi S, Morisetti A. Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?. Arh Hig Rada Toksikol. [Internet]. 2005 [pristupljeno 21.02.2019.];56(2):157-160. Dostupno na: https://hrcak.srce.hr/144
IEEE
S. Bussi i A. Morisetti, "Margins of Safety of Intravascular Contrast Media: Body Weight, Surface Area or Toxicokinetic Approach?", Arhiv za higijenu rada i toksikologiju, vol.56, br. 2, str. 157-160, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/144. [Citirano: 21.02.2019.]

Sažetak
The margin of safety of a drug is defined as the ratio between toxicity in animals and safety in humans. For intravascular contrast media, the margin of safety is traditionally the ratio between LD50 and diagnostic dose, both doses being based on bodyweight. The shift to surface area dramatically reduces this margin to unacceptable values. Toxicokinetics, which relates systemic exposure associated with early toxic signs in animals to plasma level in man, seems the most accurate and predictive criterion.

Ključne riječi
acute toxicity; diagnostic dose; LD50; toxicokinetics

Hrčak ID: 144

URI
https://hrcak.srce.hr/144

[hrvatski]

Posjeta: 2.260 *