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Pregledni rad
https://doi.org/10.2478/aiht-2018-69-3065

Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis

Aylin Elkama ; Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
Bensu Karahalil ; Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey

Puni tekst: engleski, pdf (244 KB) str. 25-31 preuzimanja: 313* citiraj
APA 6th Edition
Elkama, A. i Karahalil, B. (2018). Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis. Arhiv za higijenu rada i toksikologiju, 69 (1), 25-31. https://doi.org/10.2478/aiht-2018-69-3065
MLA 8th Edition
Elkama, Aylin i Bensu Karahalil. "Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis." Arhiv za higijenu rada i toksikologiju, vol. 69, br. 1, 2018, str. 25-31. https://doi.org/10.2478/aiht-2018-69-3065. Citirano 19.09.2020.
Chicago 17th Edition
Elkama, Aylin i Bensu Karahalil. "Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis." Arhiv za higijenu rada i toksikologiju 69, br. 1 (2018): 25-31. https://doi.org/10.2478/aiht-2018-69-3065
Harvard
Elkama, A., i Karahalil, B. (2018). 'Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis', Arhiv za higijenu rada i toksikologiju, 69(1), str. 25-31. https://doi.org/10.2478/aiht-2018-69-3065
Vancouver
Elkama A, Karahalil B. Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis. Arh Hig Rada Toksikol. [Internet]. 2018 [pristupljeno 19.09.2020.];69(1):25-31. https://doi.org/10.2478/aiht-2018-69-3065
IEEE
A. Elkama i B. Karahalil, "Role of gene polymorphisms in vitamin D metabolism and in multiple sclerosis", Arhiv za higijenu rada i toksikologiju, vol.69, br. 1, str. 25-31, 2018. [Online]. https://doi.org/10.2478/aiht-2018-69-3065

Sažetak
Multiple sclerosis (MS) is a complex inflammatory disease of the central nervous system (CNS) resulting in neurological impairment and disability. There is evidence that adequate vitamin D levels may lower the risk of MS development. The aetiology of MS is complex and involves both genetic and environmental factors. In fact, not one but several genes are believed to lead to the disease. As for environmental factors, one of the most important risk factors is vitamin D deficiency, which, in turn, is closely related to gene polymorphisms that play a role in vitamin D metabolism and regulation. However, information about these gene polymorphisms is quite contradictory. The aim of this review is to discuss the association between some of the vitamin D-related gene variants and MS.

Ključne riječi
cytochrome P; HLA-DRB1; vitamin D receptor

Hrčak ID: 196020

URI
https://hrcak.srce.hr/196020

[hrvatski]

Posjeta: 493 *