Original scientific paper

A New RL Constant for the Calculation of log P and n Values in Congeneric Compounds

D. Maysinger ; School of Pharmacy, Radiopharmacy Program, University of Southern California, Los Angeles California 90033, U.S.A.
W. Wolf ; School of Pharmacy, Radiopharmacy Program, University of Southern California, Los Angeles California 90033, U.S.A.
J. Casanova ; Department of Chemistry, California State University, Los Angeles, California 90032, U.S.A.
M. Tarle ; Department of Chemistry, California State University, Los Angeles, California 90032, U.S.A.

Abstract

Retention volumes of iodinated diethylstilbestrols and estradiols
measured by high-pressure liquid chromatography on a silica
column were found to be linearly related to their experimental
partition coefficients (log P). The log P values calculated from the
new RL parameter correlate well with experimental values and with
those calculated by Hansch :n:-constants. The magnitudes of it-values
for iodine in monosubstituted estradiols are discussed in terms of
the contribution of steric and »proximity« effects to these constants.
The reported technique may be a significant addition to the
methodology of obtaining lipophylic-hydrophylic constants in structure-
activity relationship studies.

Keywords

Hrčak ID:

196353

URI

https://hrcak.srce.hr/196353

Publication date:

20.7.1977.

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