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Aminoacyl Derivatives of 4-Thiothymidine, Cytosine, and Cytidine

V. Škarić ; Laboratory of Stereochemistry and Natural Products, »Ruder Boskovic« Institute, Zagreb, Croatia, Yugoslavia
G. Laćan ; Laboratory of Stereochemistry and Natural Products, »Ruder Boskovic« Institute, Zagreb, Croatia, Yugoslavia
Đ. Škarić ; Laboratory of Stereochemistry and Natural Products, »Ruder Boskovic« Institute, Zagreb, Croatia, Yugoslavia

Puni tekst: engleski, pdf (4 MB) str. 351-359 preuzimanja: 54* citiraj
APA 6th Edition
Škarić, V., Laćan, G. i Škarić, Đ. (1976). Aminoacyl Derivatives of 4-Thiothymidine, Cytosine, and Cytidine. Croatica Chemica Acta, 48 (3), 351-359. Preuzeto s https://hrcak.srce.hr/196466
MLA 8th Edition
Škarić, V., et al. "Aminoacyl Derivatives of 4-Thiothymidine, Cytosine, and Cytidine." Croatica Chemica Acta, vol. 48, br. 3, 1976, str. 351-359. https://hrcak.srce.hr/196466. Citirano 05.03.2021.
Chicago 17th Edition
Škarić, V., G. Laćan i Đ. Škarić. "Aminoacyl Derivatives of 4-Thiothymidine, Cytosine, and Cytidine." Croatica Chemica Acta 48, br. 3 (1976): 351-359. https://hrcak.srce.hr/196466
Harvard
Škarić, V., Laćan, G., i Škarić, Đ. (1976). 'Aminoacyl Derivatives of 4-Thiothymidine, Cytosine, and Cytidine', Croatica Chemica Acta, 48(3), str. 351-359. Preuzeto s: https://hrcak.srce.hr/196466 (Datum pristupa: 05.03.2021.)
Vancouver
Škarić V, Laćan G, Škarić Đ. Aminoacyl Derivatives of 4-Thiothymidine, Cytosine, and Cytidine. Croatica Chemica Acta [Internet]. 1976 [pristupljeno 05.03.2021.];48(3):351-359. Dostupno na: https://hrcak.srce.hr/196466
IEEE
V. Škarić, G. Laćan i Đ. Škarić, "Aminoacyl Derivatives of 4-Thiothymidine, Cytosine, and Cytidine", Croatica Chemica Acta, vol.48, br. 3, str. 351-359, 1976. [Online]. Dostupno na: https://hrcak.srce.hr/196466. [Citirano: 05.03.2021.]

Sažetak
5'-0-Triphenylmerthyl-4-thiothymidine (III) was coupled to
N-benzyloxycarbonyl-D,L-alanine or N-t-butyloxycarbonyl-L-phenylalanine
by the N,N-dicyclohexylcarbodiimide method, yielding
3'-nucleos1de esters V and VII. The removal of the protectilng
triphenylmethyl and t-butyloxycarbonyl groups of compound VII
afforded 3'-0-(L-phenylalanyl)-4-thiothymidine (IX).
Appropriately blocked glycylglycine and L-phenyla1anine were
also coupled to cytosine and 2',3'-0-isopropylidene-cytidine by the
active ester or dicyclohexylcarbodiimide method, yie1ding N-4-
acylated cytosi1ne X and cytidine XIII. It was establi,shed that the
catalytic hydrogenation of 4-N-(glycylglycyl)-cytosine (XI) over
5°/o rhodium on carbon afforded 4-N-(glycylglycyl)-5,6-dihydrocytosine
(XII) in a quantitative yield.

Hrčak ID: 196466

URI
https://hrcak.srce.hr/196466

Posjeta: 112 *