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Synthesis of the Four Structural Isomeric L-Pentapeptides of Ala. Glu. Lys. Ala. Ala. Sequence: Characterization and Correlation with the L-D-L-D-D-lsomer Related to the Peptidoglycan Peptide Chain

D. Goleš ; Tracer Laboratory, Department -of Organic Chemistry and Biochemistry, Institute »Ruder Boskovic«, 41001 Zagreb, Croatia, Yugoslavia
L. Tomić ; Tracer Laboratory, Department -of Organic Chemistry and Biochemistry, Institute »Ruder Boskovic«, 41001 Zagreb, Croatia, Yugoslavia
D. Keglević ; Tracer Laboratory, Department -of Organic Chemistry and Biochemistry, Institute »Ruder Boskovic«, 41001 Zagreb, Croatia, Yugoslavia

Puni tekst: engleski, pdf (7 MB) str. 365-378 preuzimanja: 55* citiraj
APA 6th Edition
Goleš, D., Tomić, L. i Keglević, D. (1976). Synthesis of the Four Structural Isomeric L-Pentapeptides of Ala. Glu. Lys. Ala. Ala. Sequence: Characterization and Correlation with the L-D-L-D-D-lsomer Related to the Peptidoglycan Peptide Chain. Croatica Chemica Acta, 48 (3), 365-378. Preuzeto s https://hrcak.srce.hr/196468
MLA 8th Edition
Goleš, D., et al. "Synthesis of the Four Structural Isomeric L-Pentapeptides of Ala. Glu. Lys. Ala. Ala. Sequence: Characterization and Correlation with the L-D-L-D-D-lsomer Related to the Peptidoglycan Peptide Chain." Croatica Chemica Acta, vol. 48, br. 3, 1976, str. 365-378. https://hrcak.srce.hr/196468. Citirano 26.02.2021.
Chicago 17th Edition
Goleš, D., L. Tomić i D. Keglević. "Synthesis of the Four Structural Isomeric L-Pentapeptides of Ala. Glu. Lys. Ala. Ala. Sequence: Characterization and Correlation with the L-D-L-D-D-lsomer Related to the Peptidoglycan Peptide Chain." Croatica Chemica Acta 48, br. 3 (1976): 365-378. https://hrcak.srce.hr/196468
Harvard
Goleš, D., Tomić, L., i Keglević, D. (1976). 'Synthesis of the Four Structural Isomeric L-Pentapeptides of Ala. Glu. Lys. Ala. Ala. Sequence: Characterization and Correlation with the L-D-L-D-D-lsomer Related to the Peptidoglycan Peptide Chain', Croatica Chemica Acta, 48(3), str. 365-378. Preuzeto s: https://hrcak.srce.hr/196468 (Datum pristupa: 26.02.2021.)
Vancouver
Goleš D, Tomić L, Keglević D. Synthesis of the Four Structural Isomeric L-Pentapeptides of Ala. Glu. Lys. Ala. Ala. Sequence: Characterization and Correlation with the L-D-L-D-D-lsomer Related to the Peptidoglycan Peptide Chain. Croatica Chemica Acta [Internet]. 1976 [pristupljeno 26.02.2021.];48(3):365-378. Dostupno na: https://hrcak.srce.hr/196468
IEEE
D. Goleš, L. Tomić i D. Keglević, "Synthesis of the Four Structural Isomeric L-Pentapeptides of Ala. Glu. Lys. Ala. Ala. Sequence: Characterization and Correlation with the L-D-L-D-D-lsomer Related to the Peptidoglycan Peptide Chain", Croatica Chemica Acta, vol.48, br. 3, str. 365-378, 1976. [Online]. Dostupno na: https://hrcak.srce.hr/196468. [Citirano: 26.02.2021.]

Sažetak
The synthesis of the four L-pentapeptides containing the Ala.
Glu. Lys. Ala. Ala. sequence, which differ with regard to the 'sHe
of linkage between the glutamyl-lysyl residues, is described.
In each case the chain was built by coupHng the protected N-
termi:nal dipeptide N-hydroxysuccinimide esiter (II or IV) with
the C-terminal tripeptide benzyl ester (VIII or X). The sequentially
.identical L-D-L-D-D-pentapeptide having the y-carboxy-group
of D-glutamic acid residue involved in the .peptide ·bond, was prepared
after the same general pattern. Complete deprotection of the
isomers i111 two successive steps gave the free pentapeptides which
were characterized as solid di-trifluoroacetate salts by analytical,
optical and proton NMR spectral data. The isomers were compared
by paper electrophoresis at different pH values. The alantne methyl
resonances in the NMR spectra of the a-a L-pentapeptide XVIII
and the y-a L-D-L-D-D-pentapeptide XXII were assigned by observing
the shift in spectral lines with varying pH.

Hrčak ID: 196468

URI
https://hrcak.srce.hr/196468

Posjeta: 106 *