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https://doi.org/10.2478/acph-2018-00309

Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release

JITKA MUŽÍKOVÁ ; Department of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic
ALENA KOMERSOVÁ ; Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic
VÁCLAV LOCHAŘ ; Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic
LUCIE VILDOVÁ ; Department of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic
BÁRA VOŠOUSTOVÁ ; Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic
MARTIN BARTOŠ ; Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic

Puni tekst: engleski, pdf (2 MB) str. 295-311 preuzimanja: 227* citiraj
APA 6th Edition
MUŽÍKOVÁ, J., KOMERSOVÁ, A., LOCHAŘ, V., VILDOVÁ, L., VOŠOUSTOVÁ, B. i BARTOŠ, M. (2018). Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release. Acta Pharmaceutica, 68 (3), 295-311. https://doi.org/10.2478/acph-2018-00309
MLA 8th Edition
MUŽÍKOVÁ, JITKA, et al. "Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release." Acta Pharmaceutica, vol. 68, br. 3, 2018, str. 295-311. https://doi.org/10.2478/acph-2018-00309. Citirano 16.06.2019.
Chicago 17th Edition
MUŽÍKOVÁ, JITKA, ALENA KOMERSOVÁ, VÁCLAV LOCHAŘ, LUCIE VILDOVÁ, BÁRA VOŠOUSTOVÁ i MARTIN BARTOŠ. "Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release." Acta Pharmaceutica 68, br. 3 (2018): 295-311. https://doi.org/10.2478/acph-2018-00309
Harvard
MUŽÍKOVÁ, J., et al. (2018). 'Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release', Acta Pharmaceutica, 68(3), str. 295-311. doi: https://doi.org/10.2478/acph-2018-00309
Vancouver
MUŽÍKOVÁ J, KOMERSOVÁ A, LOCHAŘ V, VILDOVÁ L, VOŠOUSTOVÁ B, BARTOŠ M. Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release. Acta Pharm. [Internet]. 2018 [pristupljeno 16.06.2019.];68(3):295-311. doi: https://doi.org/10.2478/acph-2018-00309
IEEE
J. MUŽÍKOVÁ, A. KOMERSOVÁ, V. LOCHAŘ, L. VILDOVÁ, B. VOŠOUSTOVÁ i M. BARTOŠ, "Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release", Acta Pharmaceutica, vol.68, br. 3, str. 295-311, 2018. [Online]. doi: https://doi.org/10.2478/acph-2018-00309

Sažetak
This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.

Ključne riječi
coprocessed dry binder; matrix tablets; polyvinyl alcohol; energy profile of compression; tensile strength of tablets; dissolution testing

Hrčak ID: 198440

URI
https://hrcak.srce.hr/198440

Posjeta: 294 *