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Acta Pharmaceutica, Vol. 68 No. 3, 2018.
Izvorni znanstveni članak
https://doi.org/10.2478/acph-2018-00309
Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release
JITKA MUŽÍKOVÁ
; Department of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic
ALENA KOMERSOVÁ
; Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic
VÁCLAV LOCHAŘ
; Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic
LUCIE VILDOVÁ
; Department of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic
BÁRA VOŠOUSTOVÁ
; Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic
MARTIN BARTOŠ
; Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic
| Puni tekst: engleski, pdf (2 MB) | str. 295-311 | citiraj | |
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APA 6th Edition MUŽÍKOVÁ, J., KOMERSOVÁ, A., LOCHAŘ, V., VILDOVÁ, L., VOŠOUSTOVÁ, B. i BARTOŠ, M. (2018). Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release. Acta Pharmaceutica, 68 (3), 295-311. https://doi.org/10.2478/acph-2018-00309 MLA 8th Edition MUŽÍKOVÁ, JITKA, et al. "Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release." Acta Pharmaceutica, vol. 68, br. 3, 2018, str. 295-311. https://doi.org/10.2478/acph-2018-00309. Citirano 23.02.2019. Chicago 17th Edition MUŽÍKOVÁ, JITKA, ALENA KOMERSOVÁ, VÁCLAV LOCHAŘ, LUCIE VILDOVÁ, BÁRA VOŠOUSTOVÁ i MARTIN BARTOŠ. "Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release." Acta Pharmaceutica 68, br. 3 (2018): 295-311. https://doi.org/10.2478/acph-2018-00309 Harvard MUŽÍKOVÁ, J., et al. (2018). 'Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release', Acta Pharmaceutica, 68(3), str. 295-311. doi: https://doi.org/10.2478/acph-2018-00309 Vancouver MUŽÍKOVÁ J, KOMERSOVÁ A, LOCHAŘ V, VILDOVÁ L, VOŠOUSTOVÁ B, BARTOŠ M. Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release. Acta Pharm. [Internet]. 2018 [pristupljeno 23.02.2019.];68(3):295-311. doi: https://doi.org/10.2478/acph-2018-00309 IEEE J. MUŽÍKOVÁ, A. KOMERSOVÁ, V. LOCHAŘ, L. VILDOVÁ, B. VOŠOUSTOVÁ i M. BARTOŠ, "Comparative evaluation of the using of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release", Acta Pharmaceutica, vol.68, br. 3, str. 295-311, 2018. [Online]. doi: https://doi.org/10.2478/acph-2018-00309 |
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Sažetak
This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.
Ključne riječi
coprocessed dry binder; matrix tablets; polyvinyl alcohol; energy profile of compression; tensile strength of tablets; dissolution testing
Hrčak ID: 198440
URI
https://hrcak.srce.hr/198440
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