Sažetak sa skupa
Occurrence of Non-Hodgkin Lymphoma in the Oral Cavity - Case Presentation
Pavel Kobler
Josipa Borčić
Irina Filipović-Zore
Marin Nola
Dubravka Sertić
Sažetak
Non-Hodgkin lymphomas (NHL) are a heterogenetic group of lymphoproliferative neoplasms, characterised by the occurrence of malignantly changed lymphocytes in a lymph node, and rarely primary in other organs. The disease most frequently manifests with painlessly enlarged lymph nodes, which in the gastrointestinal and urinary tract may cause compression. Infiltration of the bone marrow causes insufficiency of myelopoiesis, resulting in anaemia, trombocytopenia and neutropenia. Classification of the disease is based on PHD and peripheral blood findings.
Extranodular disease occurs most frequently in the gastrointestinal tract, and also often occurs in the sinuses, thyroid gland, salivary glands, breasts, kidneys and lungs. Approximately 25% of extranodular lymphomas first occur on the head and neck in the so called Waldeyer's ring, although primary lymphomas of the oral cavity are rare.
We present the case of a 63-year-old man with primary occurrence of NHL on the gingiva. The suspect lesion in the oral cavity was noticed during extraction of an inflamed root in the upper jaw. The lesion was located in the immediate vicinity of odontogenic inflammation, although it was not connected with it, and thus a specimen was taken for biopsy. The radiographic finding did not show anything specific. PHD finding of the lesion showed necrosis, bleeding and polymorphonuclear inflamed infiltrate and a tumorous mass with atypical lymphocyte cells. After a further examination by a haematopathologist NHL was confirmed with a high degree of B-cell malignancy. Immunohistochemistry confirmed giant cell NHL, B immunophenotype, and the patient's condition was defined as NHL II E.
Ključne riječi
Hrčak ID:
1888
URI
Datum izdavanja:
15.12.2004.
Posjeta: 2.831 *