Pregledni rad
https://doi.org/10.21857/y26kec3wk9
Isolation, characterization and differetiation potential of oral mucosa stem cells
Ivan Alajbeg
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Human oral mucosal stem cells (hOMSC) originate from the neural crest and possess multipotency, especially differentiation potential towards neuroectodermal lineage. They are easy to collect, as sampling does not result in irreversible destruction of oral tissues. Potential clinical use of hOMSC is also in the other medical fields; hOMSCs have been successfully transplanted to the cornea in patients with limbal defect, and similar cells can be differentiated into cardiomyocytes after myocardial infarction. hOMSC research in animal models of neurological diseases and injuries has shown their potential role in diseases which modern medicine has failed to treat. In this regard, we started the research of hOMSC and the possibility of their application in the model of ischemic brain stroke. After successfully isolating hOMSC and following their differentiation in the neuroectodermal and mesodermal directions, it was proved that it is possible to produce co-cultures of hOMSC mouse neural stem cells, which we see as an indicator that those cells will be able to coexist and communicate in the mouse model.
Ključne riječi
human oral mucosal stem cells; mouse neural stem cells; co-cultures; neural differentiation
Hrčak ID:
201079
URI
Datum izdavanja:
13.6.2018.
Posjeta: 970 *