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https://doi.org/10.2478/v10007-007-0050-4

Sinteza i biološko djelovanje derivata 3-{[5-(6-metil-4-aril-2-okso-1,2,3,4-tetrahidropirimidin-5-il)-1,3,4-oksadiazol-2-il] -imino}-1,3-dihidro-2H-indol-2-ona

SONIA GEORGE
MANOJ KUMAR PARAMESWARAN
ACHARJEE
RAJA CHAKRABORTY
THENGUNGAL KOCHUPAPPY RAVI

Fulltext: english, pdf (135 KB) pages 119-129 downloads: 891* cite
APA 6th Edition
GEORGE, S., PARAMESWARAN, M.K., ACHARJEE, CHAKRABORTY, R. & RAVI, T.K. (2008). Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives. Acta Pharmaceutica, 58 (1), 119-129. https://doi.org/10.2478/v10007-007-0050-4
MLA 8th Edition
GEORGE, SONIA, et al. "Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives." Acta Pharmaceutica, vol. 58, no. 1, 2008, pp. 119-129. https://doi.org/10.2478/v10007-007-0050-4. Accessed 19 Jul. 2019.
Chicago 17th Edition
GEORGE, SONIA, MANOJ KUMAR PARAMESWARAN, ACHARJEE, RAJA CHAKRABORTY and THENGUNGAL KOCHUPAPPY RAVI. "Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives." Acta Pharmaceutica 58, no. 1 (2008): 119-129. https://doi.org/10.2478/v10007-007-0050-4
Harvard
GEORGE, S., et al. (2008). 'Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives', Acta Pharmaceutica, 58(1), pp. 119-129. https://doi.org/10.2478/v10007-007-0050-4
Vancouver
GEORGE S, PARAMESWARAN MK, ACHARJEE, CHAKRABORTY R, RAVI TK. Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives. Acta Pharm. [Internet]. 2008 [cited 2019 July 19];58(1):119-129. https://doi.org/10.2478/v10007-007-0050-4
IEEE
S. GEORGE, M.K. PARAMESWARAN, ACHARJEE, R. CHAKRABORTY and T.K. RAVI, "Synthesis and evaluation of the biological activities of some 3-{[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl]-imino}-1,3-dihydro-2H-indol-2-one derivatives", Acta Pharmaceutica, vol.58, no. 1, pp. 119-129, 2008. [Online]. https://doi.org/10.2478/v10007-007-0050-4

Abstracts
Derivati 6-metil-2-okso-4-aril-1,2,3,4-tetrahidropirimidin-5-karbohidrazida (2a-i) pripravljeni su reakcijom etil-6-metil–2-okso-4-aril-1,2,3,4-tetrahidropirimidin-5-karboksilata (1a-i) i hidrazin hidrata. Iz njih su sa cijanogen bromidom priređeni 5-(5-amino-1,3,4-oksadiazol-2-il)-6-metil-4-aril-3,4-dihidropirimidin-2(1H)-oni (3a-i). Kondenzacijom nastalih aminooksadiazolilpirimidinona s izatinom dobiveni su 3-{[5-(6-metil-4-aril-2-okso-1,2-tetrahidropirimidin-5-il)-1,3,4-oksadiazol-2-il]-imino}-1,3-dihidro-2H-indol-2-oni (4a-i). Produkti 4 karakterizirani su uobičajenim spektroskopskim metodama (IR, 1H NMR, spektar masa) i elementarnom analizom. Biološko vrednovanje ukazuje da spojevi 4a-i imaju potencijalno antibakterijsko, antimikotsko i antioksidativno djelovanje.

Keywords
pirimidinil oksadiazol amini; pirimidinon oksadiazolil indolinoni; antibakterijsko; antimikotsko i antioksidativno djelovanje

Hrčak ID: 19050

URI
https://hrcak.srce.hr/19050

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