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Alcoholism and psychiatry research : Journal on psychiatric research and addictions, Vol.54 No.1 Lipanj 2018.

Izvorni znanstveni članak
https://doi.org/10.20471/may.2018.54.01.02

Low BDNF concentrations in schizophrenia may be caused by non-linearity of BDNF correlation with age caused by its interaction with sex

Maja Vilibić ; Department of Psychiatry, University Hospital Center Sestre milosrdnice, Zagreb, Croatia
Karolina Novački ; 2 Department of Medical Biochemistry and Hematology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Nada Vrkić ; 3 Department of Clinical Chemistry, University Hospital Center Sestre milosrdnice, Zagreb, Croatia
Dalibor Karlović ; Catholic University of Croatia, Zagreb, Croatia

Puni tekst: engleski, pdf (557 KB) str. 21-32 preuzimanja: 24* citiraj
APA 6th Edition
Vilibić, M., Novački, K., Vrkić, N. i Karlović, D. (2018). Low BDNF concentrations in schizophrenia may be caused by non-linearity of BDNF correlation with age caused by its interaction with sex. Alcoholism and psychiatry research, 54 (1), 21-32. https://doi.org/10.20471/may.2018.54.01.02
MLA 8th Edition
Vilibić, Maja, et al. "Low BDNF concentrations in schizophrenia may be caused by non-linearity of BDNF correlation with age caused by its interaction with sex." Alcoholism and psychiatry research, vol. 54, br. 1, 2018, str. 21-32. https://doi.org/10.20471/may.2018.54.01.02. Citirano 14.11.2018.
Chicago 17th Edition
Vilibić, Maja, Karolina Novački, Nada Vrkić i Dalibor Karlović. "Low BDNF concentrations in schizophrenia may be caused by non-linearity of BDNF correlation with age caused by its interaction with sex." Alcoholism and psychiatry research 54, br. 1 (2018): 21-32. https://doi.org/10.20471/may.2018.54.01.02
Harvard
Vilibić, M., et al. (2018). 'Low BDNF concentrations in schizophrenia may be caused by non-linearity of BDNF correlation with age caused by its interaction with sex', Alcoholism and psychiatry research, 54(1), str. 21-32. doi: https://doi.org/10.20471/may.2018.54.01.02
Vancouver
Vilibić M, Novački K, Vrkić N, Karlović D. Low BDNF concentrations in schizophrenia may be caused by non-linearity of BDNF correlation with age caused by its interaction with sex. Alcoholism and psychiatry research [Internet]. 2018 [pristupljeno 14.11.2018.];54(1):21-32. doi: https://doi.org/10.20471/may.2018.54.01.02
IEEE
M. Vilibić, K. Novački, N. Vrkić i D. Karlović, "Low BDNF concentrations in schizophrenia may be caused by non-linearity of BDNF correlation with age caused by its interaction with sex", Alcoholism and psychiatry research, vol.54, br. 1, str. 21-32, 2018. [Online]. doi: https://doi.org/10.20471/may.2018.54.01.02
Puni tekst: hrvatski, pdf (557 KB) str. 21-32 preuzimanja: 42* citiraj
APA 6th Edition
Vilibić, M., Novački, K., Vrkić, N. i Karlović, D. (2018). Niske koncentracije BDNF-a u shizofreniji su možebitno uzrokovane nelinearnošću korelacije BDNF-a s dobi koja je uzrokovana interakcijom sa spolom. Alcoholism and psychiatry research, 54 (1), 21-32. https://doi.org/10.20471/may.2018.54.01.02
MLA 8th Edition
Vilibić, Maja, et al. "Niske koncentracije BDNF-a u shizofreniji su možebitno uzrokovane nelinearnošću korelacije BDNF-a s dobi koja je uzrokovana interakcijom sa spolom." Alcoholism and psychiatry research, vol. 54, br. 1, 2018, str. 21-32. https://doi.org/10.20471/may.2018.54.01.02. Citirano 14.11.2018.
Chicago 17th Edition
Vilibić, Maja, Karolina Novački, Nada Vrkić i Dalibor Karlović. "Niske koncentracije BDNF-a u shizofreniji su možebitno uzrokovane nelinearnošću korelacije BDNF-a s dobi koja je uzrokovana interakcijom sa spolom." Alcoholism and psychiatry research 54, br. 1 (2018): 21-32. https://doi.org/10.20471/may.2018.54.01.02
Harvard
Vilibić, M., et al. (2018). 'Niske koncentracije BDNF-a u shizofreniji su možebitno uzrokovane nelinearnošću korelacije BDNF-a s dobi koja je uzrokovana interakcijom sa spolom', Alcoholism and psychiatry research, 54(1), str. 21-32. doi: https://doi.org/10.20471/may.2018.54.01.02
Vancouver
Vilibić M, Novački K, Vrkić N, Karlović D. Niske koncentracije BDNF-a u shizofreniji su možebitno uzrokovane nelinearnošću korelacije BDNF-a s dobi koja je uzrokovana interakcijom sa spolom. Alcoholism and psychiatry research [Internet]. 2018 [pristupljeno 14.11.2018.];54(1):21-32. doi: https://doi.org/10.20471/may.2018.54.01.02
IEEE
M. Vilibić, K. Novački, N. Vrkić i D. Karlović, "Niske koncentracije BDNF-a u shizofreniji su možebitno uzrokovane nelinearnošću korelacije BDNF-a s dobi koja je uzrokovana interakcijom sa spolom", Alcoholism and psychiatry research, vol.54, br. 1, str. 21-32, 2018. [Online]. doi: https://doi.org/10.20471/may.2018.54.01.02

Sažetak
Considerable inconsistencies exist between results of the studies on brain-derived neurotrophic factor (BDNF) peripheral concentrations and schizophrenia (SCH). The objective of our study was to check whether these inconsistencies may be explained by confounding effects of age and sex. In this cross-sectional study performed during 2017 at Department of Psychiatry, University Hospital Center Sestre milosrdnice, Zagreb, Croatia, we included a sample of 41 patients diagnosed with SCH. The main outcome was BDNF serum concentrations. We have detected a significant cross-over interaction of sex and age on BDNF concentration (p=0.017). In male patients BNDF concentrations significantly increase with age. In female patients the correlation between age and BDNF was not significant. On this particular sample level, it was negative: aging was associated with the decrease of BDNF concentrations in female patients. BDNF concentrations were significantly different between female and male patients under the age of 22 years (total of 7% of patients), and above the age of 65 (total of 10% of patients). BDNF may be a promising schizophrenia biomarker, but different norms should be proposed for the patients of different age and sex.

Ključne riječi
Brain-derived neurotrophic factor (BDNF); schizophrenia; biomarker; age; sex

Hrčak ID: 203336

URI
https://hrcak.srce.hr/203336

[hrvatski]

Posjeta: 131 *