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Review article

Molecular Genetics - the Future of Oncology

Boris Labar

Fulltext: croatian, pdf (169 KB) pages 141-145 downloads: 1.568* cite
APA 6th Edition
Labar, B. (2001). Molekularna genetika - budućnost onkologije. Medicus, 10 (2_Maligni tumori), 141-145. Retrieved from
MLA 8th Edition
Labar, Boris. "Molekularna genetika - budućnost onkologije." Medicus, vol. 10, no. 2_Maligni tumori, 2001, pp. 141-145. Accessed 17 Apr. 2021.
Chicago 17th Edition
Labar, Boris. "Molekularna genetika - budućnost onkologije." Medicus 10, no. 2_Maligni tumori (2001): 141-145.
Labar, B. (2001). 'Molekularna genetika - budućnost onkologije', Medicus, 10(2_Maligni tumori), pp. 141-145. Available at: (Accessed 17 April 2021)
Labar B. Molekularna genetika - budućnost onkologije. Medicus [Internet]. 2001 [cited 2021 April 17];10(2_Maligni tumori):141-145. Available from:
B. Labar, "Molekularna genetika - budućnost onkologije", Medicus, vol.10, no. 2_Maligni tumori, pp. 141-145, 2001. [Online]. Available: [Accessed: 17 April 2021]

New insights of molecular mechanisms on
the biology of cancer are reported. The possible mechanism
and disturbance of signaling pathways for cell growth important
for cancer transformation is discussed. Perturbations
and oncogene mutations of signal transduction in cancer disturbance
might be changed by the cell membrane receptor,
intracellular signaling and nuclear transcriptional factors.
Mutation of tumor suppressor genes and deregulation of apoptosis
are also important in cancerogenesis. In the second
part of the text the new molecular techniques important for
diagnosis and prognosis of cancer are described. cDNA microarrays
are a new tool to analyzy gene expression patterns
in human cancer. Molecular classification of tumors into general
categories of gene expression can potentially identify previously
undetected and clinically significant subtypes of cancer.
The first major clinical correlation of gene expression patterns
with disease outcome was documented in diffuse large
B-cell lymphoma. By gene-chip arrays this lymphoma is divided
into two molecularly distinct forms with different survival.

oncogenes; tumor supressor genes; apoptosis; gene-chip arrays

Hrčak ID: 19342



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