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Izvorni znanstveni članak
https://doi.org/10.2478/acph-2019-0005

Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines

AFFIDAH SABRAN ; Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
ENDANG KUMOLOSASI   ORCID icon orcid.org/0000-0002-7688-5250 ; Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

Puni tekst: engleski, pdf (2 MB) str. 75-86 preuzimanja: 170* citiraj
APA 6th Edition
SABRAN, A. i KUMOLOSASI, E. (2019). Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines. Acta Pharmaceutica, 69 (1), 75-86. https://doi.org/10.2478/acph-2019-0005
MLA 8th Edition
SABRAN, AFFIDAH i ENDANG KUMOLOSASI. "Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines." Acta Pharmaceutica, vol. 69, br. 1, 2019, str. 75-86. https://doi.org/10.2478/acph-2019-0005. Citirano 24.10.2020.
Chicago 17th Edition
SABRAN, AFFIDAH i ENDANG KUMOLOSASI. "Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines." Acta Pharmaceutica 69, br. 1 (2019): 75-86. https://doi.org/10.2478/acph-2019-0005
Harvard
SABRAN, A., i KUMOLOSASI, E. (2019). 'Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines', Acta Pharmaceutica, 69(1), str. 75-86. https://doi.org/10.2478/acph-2019-0005
Vancouver
SABRAN A, KUMOLOSASI E. Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines. Acta Pharm. [Internet]. 2019 [pristupljeno 24.10.2020.];69(1):75-86. https://doi.org/10.2478/acph-2019-0005
IEEE
A. SABRAN i E. KUMOLOSASI, "Effects of annexin A1 on apoptosis and cell cycle arrest in human leukemic cell lines", Acta Pharmaceutica, vol.69, br. 1, str. 75-86, 2019. [Online]. https://doi.org/10.2478/acph-2019-0005

Sažetak
Recent studies suggest that annexin A1 (ANXA1) promotes apoptosis in cancerous cells. This study aims to investigate the effects of ANXA1 on apoptosis and cell cycle arrest in K562, Jurkat and U937 cells and peripheral blood mononuclear cells (PBMC). Cells were treated with ANXA1 and cyclophosphamide prior to flow cytometry analysis for apoptosis and cell cycle arrest induction. At 2.5µM, ANXA1 induced significant apoptosis in K562 (p ≤ 0.001) and U937 (p ≤ 0.05) cells, with EC50 values of 3.6 and 3.8 µM, respectively. In Jurkat cells, induction was not significant (EC50, 17.0 µM). No significant apoptosis induction was observed in PBMC. ANXA1 caused cycle arrest in the G0/G1 phase in K562 and U937 cells with p ≤ 0.001 for both, and (p ≤ 0.01) for Jurkat cells. ANXA1 induced apoptosis and cycle arrest in the G0/G1 phase in K562 and U937 cells, causing only cell cycle arrest in Jurkat cells.

Ključne riječi
annexin A1; apoptosis; cell cycle; flow cytometry; human leukemic cell lines

Hrčak ID: 206644

URI
https://hrcak.srce.hr/206644

Posjeta: 289 *