hrcak mascot   Srce   HID

Stručni rad

A COMPARISON OF THE EFFECTIVENESS OF TOCILIZUMAB AND TNF-α INHIBITORS IN THE TREATMENT OF RHEUMATOID ARTHRITIS

Felina Anić
Marcela Bašić
Tatjana Zekić
Mladen Defranceschi
Srđan Novak

Puni tekst: hrvatski, pdf (143 KB) str. 0-0 preuzimanja: 125* citiraj
APA 6th Edition
Anić, F., Bašić, M., Zekić, T., Defranceschi, M. i Novak, S. (2018). USPOREDBA UČINKOVITOSTI TOCILIZUMABA I INHIBITORA TNF-α U LIJEČENJU REUMATOIDNOG ARTRITISA. Reumatizam, 65 (1), 0-0. Preuzeto s https://hrcak.srce.hr/207088
MLA 8th Edition
Anić, Felina, et al. "USPOREDBA UČINKOVITOSTI TOCILIZUMABA I INHIBITORA TNF-α U LIJEČENJU REUMATOIDNOG ARTRITISA." Reumatizam, vol. 65, br. 1, 2018, str. 0-0. https://hrcak.srce.hr/207088. Citirano 13.07.2020.
Chicago 17th Edition
Anić, Felina, Marcela Bašić, Tatjana Zekić, Mladen Defranceschi i Srđan Novak. "USPOREDBA UČINKOVITOSTI TOCILIZUMABA I INHIBITORA TNF-α U LIJEČENJU REUMATOIDNOG ARTRITISA." Reumatizam 65, br. 1 (2018): 0-0. https://hrcak.srce.hr/207088
Harvard
Anić, F., et al. (2018). 'USPOREDBA UČINKOVITOSTI TOCILIZUMABA I INHIBITORA TNF-α U LIJEČENJU REUMATOIDNOG ARTRITISA', Reumatizam, 65(1), str. 0-0. Preuzeto s: https://hrcak.srce.hr/207088 (Datum pristupa: 13.07.2020.)
Vancouver
Anić F, Bašić M, Zekić T, Defranceschi M, Novak S. USPOREDBA UČINKOVITOSTI TOCILIZUMABA I INHIBITORA TNF-α U LIJEČENJU REUMATOIDNOG ARTRITISA. Reumatizam [Internet]. 2018 [pristupljeno 13.07.2020.];65(1):0-0. Dostupno na: https://hrcak.srce.hr/207088
IEEE
F. Anić, M. Bašić, T. Zekić, M. Defranceschi i S. Novak, "USPOREDBA UČINKOVITOSTI TOCILIZUMABA I INHIBITORA TNF-α U LIJEČENJU REUMATOIDNOG ARTRITISA", Reumatizam, vol.65, br. 1, str. 0-0, 2018. [Online]. Dostupno na: https://hrcak.srce.hr/207088. [Citirano: 13.07.2020.]

Sažetak
Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune disease. Th e main role in the pathogenesis of RA is played by interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α). The objectives of this study were to compare the efficacy of tocilizumab and TNF-α inhibitors in RA patients who did not receive previous biological therapy, to determine how parameters of inflammation changed within each group and between the two groups, and to analyze drug retention rates after 18 months of treatment. The research included 26 patients (10 tocilizumab, 16 TNF-α inhibitors) who started biological therapy in the period between January 2011 and June 2015 and were followed for 18 months. The recorded parameters were C-reactive protein (CRP), the Disease Activity Score 28 (DAS 28 score), and the number of tender and swollen joints. Aft er 3 months of treatment the DAS 28 score was significantly lower in patients treated with tocilizumab compared with patients treated with TNF-α inhibitors (P=0.009). In both patient groups the number of tender joints was significantly reduced. In patients treated with tocilizumab the number of swollen joints was significantly reduced aft er 3 months of tocilizumab treatment, while in patients treated with TNF-α inhibitors this change was not observed. Th e mean values of CRP in both groups did not diff er significantly during the study period. In the patients treated with tocilizumab there was no discontinuation of treatment, while in patients treated with TNFα inhibitors therapy was interrupted in 7 patients (44%). Remission in RA patients occurred as soon as 3 months aft er tocilizumab treatment, while in patients treated with TNF-α inhibitors it occurred within a period of 3 to 6 months.

Ključne riječi
Arthritis, rheumatoid; Antirheumatic agents; Biological products; Antibodies, monoclonal; Tumor necrosis factor-alpha – antagonists and inhibitors; Treatment outcome; Remission induction

Hrčak ID: 207088

URI
https://hrcak.srce.hr/207088

[hrvatski]

Posjeta: 229 *