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https://doi.org/10.20471/acc.2018.57.02.18

T-Cell Large Granular Lymphocytic Leukemia – Case Report

Sandra Kojić Katović   ORCID icon orcid.org/0000-0003-4246-4260 ; Department of Cytology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia;
Ankica Vasilj   ORCID icon orcid.org/0000-0002-6784-1854 ; Department of Cytology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia;
Goran Rinčić ; Department of Hematology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia

Puni tekst: engleski, pdf (689 KB) str. 362-364 preuzimanja: 108* citiraj
APA 6th Edition
Kojić Katović, S., Vasilj, A. i Rinčić, G. (2018). T-Cell Large Granular Lymphocytic Leukemia – Case Report. Acta clinica Croatica, 57 (2), 362-364. https://doi.org/10.20471/acc.2018.57.02.18
MLA 8th Edition
Kojić Katović, Sandra, et al. "T-Cell Large Granular Lymphocytic Leukemia – Case Report." Acta clinica Croatica, vol. 57, br. 2, 2018, str. 362-364. https://doi.org/10.20471/acc.2018.57.02.18. Citirano 18.06.2019.
Chicago 17th Edition
Kojić Katović, Sandra, Ankica Vasilj i Goran Rinčić. "T-Cell Large Granular Lymphocytic Leukemia – Case Report." Acta clinica Croatica 57, br. 2 (2018): 362-364. https://doi.org/10.20471/acc.2018.57.02.18
Harvard
Kojić Katović, S., Vasilj, A., i Rinčić, G. (2018). 'T-Cell Large Granular Lymphocytic Leukemia – Case Report', Acta clinica Croatica, 57(2), str. 362-364. doi: https://doi.org/10.20471/acc.2018.57.02.18
Vancouver
Kojić Katović S, Vasilj A, Rinčić G. T-Cell Large Granular Lymphocytic Leukemia – Case Report. Acta clinica Croatica [Internet]. 2018 [pristupljeno 18.06.2019.];57(2):362-364. doi: https://doi.org/10.20471/acc.2018.57.02.18
IEEE
S. Kojić Katović, A. Vasilj i G. Rinčić, "T-Cell Large Granular Lymphocytic Leukemia – Case Report", Acta clinica Croatica, vol.57, br. 2, str. 362-364, 2018. [Online]. doi: https://doi.org/10.20471/acc.2018.57.02.18

Sažetak
T-cell large granular lymphocytic leukemia (T-LGLL) is an uncommon but probably underdiagnosed disease caused by clonal proliferation of large granular lymphocytes. Diagnosis is typically based on the high number of morphologically characteristic lymphoid cells and finding of an abnormal immunophenotype by flow cytometry. Because of its relatively indolent clinical behavior, observation is often an appropriate therapy. Here we present a case of a 53-year-old male admitted to the hospital because of abdominal pain. Blood examination revealed mild mycrocitic anemia and multiplied lactate dehydrogenase level. Abdominal ultrasound showed splenomegaly of 16 cm, with no lymphadenopathy. Fine needle aspiration of bone marrow revealed hypocellular marrow with 50% of atypical lymphoid cells. There were 81% of atypical medium sized granular lymphocytes with ir-regularly shaped nuclei in peripheral blood, so the cytologic diagnosis was lymphoproliferative proc-ess. Bone marrow biopsy showed nodular and interstitial proliferation of small, partially atypical T lymphocytic cells positive for CD2, CD3, CD5, CD8, granzyme and TIA, and negative for hairy cell markers, CD10, MUM 1, bcl 1, CD4 and CD56. The finding was consistent with T-LGLL. Due to splenomegaly, the patient was treated with cyclosporine and gradually reduced dose of corticoster-oids, leading to regression of splenomegaly and normalization of lactate dehydrogenase level.

Ključne riječi
Leukemia, Large Granular Lymphocytic; Cell Proliferation; Lymphocytes; Immunophenotyping; Flow Cytometry; Splenomegaly

Hrčak ID: 207564

URI
https://hrcak.srce.hr/207564

[hrvatski]

Posjeta: 241 *