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Pregledni rad
https://doi.org/10.2478/aiht-2018-69-3204

Sodium-glucose cotransporters: new targets of cancer therapy?

Ivana Vrhovac Madunić ; Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia
Josip Madunić ; Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia
Davorka Breljak ; Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia
Dean Karaica ; Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia
Ivan Sabolić ; Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia

Puni tekst: engleski, pdf (667 KB) str. 278-284 preuzimanja: 177* citiraj
APA 6th Edition
Vrhovac Madunić, I., Madunić, J., Breljak, D., Karaica, D. i Sabolić, I. (2018). Sodium-glucose cotransporters: new targets of cancer therapy?. Arhiv za higijenu rada i toksikologiju, 69 (4), 278-284. https://doi.org/10.2478/aiht-2018-69-3204
MLA 8th Edition
Vrhovac Madunić, Ivana, et al. "Sodium-glucose cotransporters: new targets of cancer therapy?." Arhiv za higijenu rada i toksikologiju, vol. 69, br. 4, 2018, str. 278-284. https://doi.org/10.2478/aiht-2018-69-3204. Citirano 13.12.2019.
Chicago 17th Edition
Vrhovac Madunić, Ivana, Josip Madunić, Davorka Breljak, Dean Karaica i Ivan Sabolić. "Sodium-glucose cotransporters: new targets of cancer therapy?." Arhiv za higijenu rada i toksikologiju 69, br. 4 (2018): 278-284. https://doi.org/10.2478/aiht-2018-69-3204
Harvard
Vrhovac Madunić, I., et al. (2018). 'Sodium-glucose cotransporters: new targets of cancer therapy?', Arhiv za higijenu rada i toksikologiju, 69(4), str. 278-284. https://doi.org/10.2478/aiht-2018-69-3204
Vancouver
Vrhovac Madunić I, Madunić J, Breljak D, Karaica D, Sabolić I. Sodium-glucose cotransporters: new targets of cancer therapy?. Arh Hig Rada Toksikol. [Internet]. 2018 [pristupljeno 13.12.2019.];69(4):278-284. https://doi.org/10.2478/aiht-2018-69-3204
IEEE
I. Vrhovac Madunić, J. Madunić, D. Breljak, D. Karaica i I. Sabolić, "Sodium-glucose cotransporters: new targets of cancer therapy?", Arhiv za higijenu rada i toksikologiju, vol.69, br. 4, str. 278-284, 2018. [Online]. https://doi.org/10.2478/aiht-2018-69-3204

Sažetak
Glucose, the key source of metabolic energy, is imported into cells by two categories of transporters: 1) facilitative glucose transporters (GLUTs) and 2) secondary active sodium-glucose cotransporters (SGLTs). Cancer cells have an increased demand for glucose uptake and utilisation compared to normal cells. Previous studies have demonstrated the overexpression of GLUTs, mainly GLUT1, in many cancer types. As the current standard positron emission tomography (PET) tracer 2-deoxy-2-(18F)fluoro-D-glucose (2-FDG) for imaging tumour cells via GLUT1 lacks in sensitivity and specificity, it may soon be replaced by the newly designed, highly sensitive and specific SGLT tracer α-methyl-4-(F-18)fluoro-4-deoxy-Dglucopyranoside (Me-4FDG) in clinical detection and tumour staging. This tracer has recently demonstrated the functional activity of SGLT in pancreatic, prostate, and brain cancers. The mRNA and protein expression of SGLTs have also been reported in colon/colorectal, lung, ovarian, head, neck, and oral squamous carcinomas. So far, SGLTs have been poorly investigated in cancer, and their protein expression and localisation are often controversial due to a lack of specific SGLT antibodies. In this review, we describe current knowledge concerning SGLT1 and SGLT2 (over)expression in various cancer types. The findings of SGLTs in malignant cells may help in developing novel cancer therapies with SGLT2 or SGLT1/SGLT2 inhibitors already used in diabetes mellitus treatment.

Ključne riječi
brain cancer; Na+-dependent glucose transporters; pancreatic cancer; positron emission tomography; prostate cancer; SGLT inhibitors

Hrčak ID: 213618

URI
https://hrcak.srce.hr/213618

[hrvatski]

Posjeta: 300 *