Infektološki glasnik, Vol. 37 No. 1, 2017.
Izvorni znanstveni članak
The treatment of chronic hepatitis B virus infection at the University Hospital for Infectious Diseases "Dr. Fran Mihaljević" in Zagreb in the period from 2008 to 2017
Ivan Kurelac
; Klinika za infektivne bolesti
Davorka Dušek
; Klinika za infektivne bolesti
Neven Papić
; Klinika za infektivne bolesti
Jelena Mihalić
; Klinika za infektivne bolesti
Juraj Krznarić
; Klinika za infektivne bolesti
Snježana Židovec Lepej
; Klinika za infektivne bolesti
Oktavija Đaković Rode
; Klinika za infektivne bolesti
Adriana Vince
; Klinika za infektivne bolesti
Sažetak
A total of 210 patients with chronic HBV infection and histological and biochemical activity of disease were treated at the University Hospital for Infectious Diseases "Dr. Fran Mihaljević" in Zagreb in the period from 2008 to 2017. The fibrosis stage was determined histologically and by transient elastography, and cirrhosis was found initially in 14,5 % of the patients. Although functional recovery was rare (5.5 % of cases), the suppression of viral replication, slowing down or discontinuation of fibrosis progression was achieved in most of the treated. Even fibrosis regression by one stage in Metavir scale was achieved in 16 % of patients. There was also a decrease in the frequency of development of
decompensated cirrhosis (2 patients) and hepatocellular carcinoma (2 patients) by 2 to 3 times in comparison to historical controls in nontreated patients. Patients treated with lamivudine had a high incidence of resistance development (32 % after 5 years). They continued therapy with tenofovir with good tolerability and no resistance development. HBeAg did not seem to be a significant predictor
for the severity and the course of the disease. There is also a significant
number of hematologic and other immunosuppressed patients (n = 24) receiving treatment to prevent the reactivation of latent HBV infection.
Ključne riječi
chronic hepatitis B; treatment; nucleoside and nucleotide analogues
Hrčak ID:
216060
URI
Datum izdavanja:
22.1.2019.
Posjeta: 1.533 *