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https://doi.org/10.5562/cca3418

Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity

Sakharam B. Dongare ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University Solapur, Maharashtra, India-413255
Babasaheb. P. Bandgar ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University Solapur, Maharashtra, India-413255
Pravin S. Bhale ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University Solapur, Maharashtra, India-413255
Sadanand N. Shringare ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University Solapur, Maharashtra, India-413255
Hemant V. Chavan   ORCID icon orcid.org/0000-0002-2429-6470 ; Medicinal Chemistry Research Laboratory, School of Chemical Sciences, Solapur University Solapur, Maharashtra, India-413255

Puni tekst: engleski, pdf (2 MB) str. 1-9 preuzimanja: 501* citiraj
APA 6th Edition
Dongare, S.B., Bandgar, B.P., Bhale, P.S., Shringare, S.N. i Chavan, H.V. (2019). Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity. Croatica Chemica Acta, 92 (1), 1-9. https://doi.org/10.5562/cca3418
MLA 8th Edition
Dongare, Sakharam B., et al. "Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity." Croatica Chemica Acta, vol. 92, br. 1, 2019, str. 1-9. https://doi.org/10.5562/cca3418. Citirano 02.03.2021.
Chicago 17th Edition
Dongare, Sakharam B., Babasaheb. P. Bandgar, Pravin S. Bhale, Sadanand N. Shringare i Hemant V. Chavan. "Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity." Croatica Chemica Acta 92, br. 1 (2019): 1-9. https://doi.org/10.5562/cca3418
Harvard
Dongare, S.B., et al. (2019). 'Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity', Croatica Chemica Acta, 92(1), str. 1-9. https://doi.org/10.5562/cca3418
Vancouver
Dongare SB, Bandgar BP, Bhale PS, Shringare SN, Chavan HV. Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity. Croatica Chemica Acta [Internet]. 2019 [pristupljeno 02.03.2021.];92(1):1-9. https://doi.org/10.5562/cca3418
IEEE
S.B. Dongare, B.P. Bandgar, P.S. Bhale, S.N. Shringare i H.V. Chavan, "Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity", Croatica Chemica Acta, vol.92, br. 1, str. 1-9, 2019. [Online]. https://doi.org/10.5562/cca3418

Sažetak
A series of 7-azaindolyl hydrazones were prepared by reacting of hydrazides of 7-azaindole-3-acetic acids with aromatic aldehydes and N-substituted indolyl-3-carboxyaldehydes. Structure of all the synthesized compounds were satisfactorily correlated by IR, 1H NMR, 13C NMR and mass spectroscopic evidences. The synthesized compounds were evaluated for their possible anticancer potential against MCF-7 induced breast carcinoma. It is worth mentioning that most of the compounds were considerably active against MCF-7 cell line with GI50 values ranging from 22.3–81.0 μM. The hydrazones of N-1-substituted indole-3-carboxyaldehydes 9f, 9g, 9h, 9c, and 9j were active against MCF-7 cell line with GI50 values less than 40 μM (GI50 = 22.3 and 24.9, 29.6, 30.2 and 37.8 μM respectively) with moderate TGI values (TGI = 56.6, 59.5, 65.5, 70.7 and 94.6 μM respectively). The active compounds were also screened against the normal Vero monkey cell line, which showed moderate selectivity against inhibition of cancer cells.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
7-azaindole; hydrazone; breast carcinoma

Hrčak ID: 217509

URI
https://hrcak.srce.hr/217509

Posjeta: 889 *