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Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus

Parthena Meltzanidou ; 1. 2nd Dermatology Department, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece 2. Department of Biological Applications and Technologies, University of Ioannina, Ioannina, Greece. & Interscience Molecular Onco
Aikaterini Patsatsi   ORCID icon orcid.org/0000-0001-9616-2001 ; 2nd Dermatology Department, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece
Aikaterini Kyriakou   ORCID icon orcid.org/0000-0002-7594-8512 ; 2nd Dermatology Department, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece
Katerina Vareli ; 2. Department of Biological Applications and Technologies, University of Ioannina, Ioannina, Greece. & Interscience Molecular Oncology Laboratory (iMol), University of Ioannina Cancer Biobank Center (UICBC), Ioannina, Greece.
Alexandros Lambropoulos ; 3. Molecular Biology Laboratory, 1st Department of Obstetrics and Gynecology, Aristotle University School of Medicine, Papageorgiou General Hospital, Thessaloniki, Greece

Puni tekst: engleski, PDF (102 KB) str. 8-8 preuzimanja: 82* citiraj
APA 6th Edition
Meltzanidou, P., Patsatsi, A., Kyriakou, A., Vareli, K. i Lambropoulos, A. (2019). Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus. Acta Dermatovenerologica Croatica, 27 (1), 8-8. Preuzeto s https://hrcak.srce.hr/219582
MLA 8th Edition
Meltzanidou, Parthena, et al. "Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus." Acta Dermatovenerologica Croatica, vol. 27, br. 1, 2019, str. 8-8. https://hrcak.srce.hr/219582. Citirano 17.10.2021.
Chicago 17th Edition
Meltzanidou, Parthena, Aikaterini Patsatsi, Aikaterini Kyriakou, Katerina Vareli i Alexandros Lambropoulos. "Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus." Acta Dermatovenerologica Croatica 27, br. 1 (2019): 8-8. https://hrcak.srce.hr/219582
Harvard
Meltzanidou, P., et al. (2019). 'Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus', Acta Dermatovenerologica Croatica, 27(1), str. 8-8. Preuzeto s: https://hrcak.srce.hr/219582 (Datum pristupa: 17.10.2021.)
Vancouver
Meltzanidou P, Patsatsi A, Kyriakou A, Vareli K, Lambropoulos A. Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus. Acta Dermatovenerol Croat. [Internet]. 2019 [pristupljeno 17.10.2021.];27(1):8-8. Dostupno na: https://hrcak.srce.hr/219582
IEEE
P. Meltzanidou, A. Patsatsi, A. Kyriakou, K. Vareli i A. Lambropoulos, "Detection of IgG autoantibodies against desmocollin–3 in Greek patients with pemphigus", Acta Dermatovenerologica Croatica, vol.27, br. 1, str. 8-8, 2019. [Online]. Dostupno na: https://hrcak.srce.hr/219582. [Citirano: 17.10.2021.]

Sažetak

Pemphigus is an autoimmune bullous disorder caused by autoantibodies against desmosomal cadherins. The most common clinical forms are pemphigus vulgaris (PV) and pemphigus foliaceus (PF). Among the numerous proteins that are considered responsible for the cohesion of keratinocytes in epidermis, desmocollin-3 (Dsc-3) has been initially reported to participate in epidermal blistering in mice. There have been reports in which autoantibodies against Dsc-3 have been detected. In PV, a limited number of studies found no presence of IgG or IgA autoantibodies against Dsc-3. In this study we examined sera from Greek patients with PV and PF for the presence of IgG autoantibodies against Dsc-3. Immunoblotting for the detection of autoantibodies against Dsc-3 was performed in sera from all cases. Dsc-3 autoantibodies were not detected in either group (PV and PF). Our results confirm the hypothesis that the pathogenic role of Dsc-3 in epidermal blistering in PV and PF remains controversial.

 

Hrčak ID: 219582

URI
https://hrcak.srce.hr/219582

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