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Meeting abstract

Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine

Pavla Peraić
Dominik Malekinuić
Emma Orešković
Borna Vrdoljak
Filip Radevski
Josh Fry
Oliver Marcel Koltay

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APA 6th Edition
Peraić, P., Malekinuić, D., Orešković, E., Vrdoljak, B., Radevski, F., Fry, J. & Koltay, O.M. (2019). Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine. Liječnički vjesnik, 141 (suppl.1), 0-0. Retrieved from https://hrcak.srce.hr/221483
MLA 8th Edition
Peraić, Pavla, et al. "Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine." Liječnički vjesnik, vol. 141, no. suppl.1, 2019, pp. 0-0. https://hrcak.srce.hr/221483. Accessed 25 Jan. 2020.
Chicago 17th Edition
Peraić, Pavla, Dominik Malekinuić, Emma Orešković, Borna Vrdoljak, Filip Radevski, Josh Fry and Oliver Marcel Koltay. "Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine." Liječnički vjesnik 141, no. suppl.1 (2019): 0-0. https://hrcak.srce.hr/221483
Harvard
Peraić, P., et al. (2019). 'Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine', Liječnički vjesnik, 141(suppl.1), pp. 0-0. Available at: https://hrcak.srce.hr/221483 (Accessed 25 January 2020)
Vancouver
Peraić P, Malekinuić D, Orešković E, Vrdoljak B, Radevski F, Fry J, et al. Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine. Liječnički vjesnik [Internet]. 2019 [cited 2020 January 25];141(suppl.1):0-0. Available from: https://hrcak.srce.hr/221483
IEEE
P. Peraić, et al., "Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine", Liječnički vjesnik, vol.141, no. suppl.1, pp. 0-0, 2019. [Online]. Available: https://hrcak.srce.hr/221483. [Accessed: 25 January 2020]

Abstracts
Pentadecapeptide BPC 157 was previously shown as a cardioprotective compound in a model of arrhythmia induced by bupivacaine toxicity where it counteracts arrhythmias and prevents lethal outcome much like in other cardiotoxicity mainly related to potassium disturbances, both hyperkalemia and hypokalemia, in vivo and in vitro. We wanted to explore does BPC 157 antagonize effect of lidocai We used Wistar Albino male rats, underwent regional blocks with lidocaine (spinal intrathecal block (lidocaine 6 mg/kg, 0.1 ml/rat, 550 gb.w.) or axillary block (lidocaine 15 mg/kg, 0.3 ml/rat, 220 g b.w.). Rats received BPC 157 (10 μg, 10 ng, 10 pg/kg intraperitoneally or intragastrically) or an equivolume of saline (5 ml/kg), either immediately or at 10 min when local anesthesia was fully established. While lidocaine application produced a prolong function failure, all BPC 157 regimens significantly shortened time to full function recovery in the conditions of full local anesthesia. In other experiments, using a hot plate (55o C for 3 minutes) when rat hind paws were infiltrated with 2% lidocaine (0.1 ml/paw), a subsequent infiltration with BPC 157 (10 μg, 10 ng, 10 pg/kg) results in the faster feet lifting and much less edema. ECG recording documented that the regimens of BPC 157 counteracted the lidocaine-induced arrhythmias. Therefore, it may be possible that BPC 157 acts as the missing antidote to local anesthethics, and potentially deleterious and even life threatening adverse effects of toxic doses of local anesthethics would be markedly attenuated or even abolished.

Keywords
BPC, lidocaine, antagonize

Hrčak ID: 221483

URI
https://hrcak.srce.hr/221483

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