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Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine

Mariam Samara ; School of Medicine, University of Zagreb, Zagreb, Croatia
Vilim Dretar ; School of Medicine, University of Zagreb, Zagreb, Croatia
Helena Žižek ; School of Medicine University of Zagreb
Emma Orešković ; School of Medicine, University of Zagreb, Zagreb, Croatia
Filip Radevski ; School of Medicine, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (69 KB) str. 0-0 preuzimanja: 18* citiraj
APA 6th Edition
Samara, M., Dretar, V., Žižek, H., Orešković, E. i Radevski, F. (2019). Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine. Liječnički vjesnik, 141 (suppl.1), 0-0. Preuzeto s https://hrcak.srce.hr/221771
MLA 8th Edition
Samara, Mariam, et al. "Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine." Liječnički vjesnik, vol. 141, br. suppl.1, 2019, str. 0-0. https://hrcak.srce.hr/221771. Citirano 21.02.2020.
Chicago 17th Edition
Samara, Mariam, Vilim Dretar, Helena Žižek, Emma Orešković i Filip Radevski. "Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine." Liječnički vjesnik 141, br. suppl.1 (2019): 0-0. https://hrcak.srce.hr/221771
Harvard
Samara, M., et al. (2019). 'Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine', Liječnički vjesnik, 141(suppl.1), str. 0-0. Preuzeto s: https://hrcak.srce.hr/221771 (Datum pristupa: 21.02.2020.)
Vancouver
Samara M, Dretar V, Žižek H, Orešković E, Radevski F. Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine. Liječnički vjesnik [Internet]. 2019 [pristupljeno 21.02.2020.];141(suppl.1):0-0. Dostupno na: https://hrcak.srce.hr/221771
IEEE
M. Samara, V. Dretar, H. Žižek, E. Orešković i F. Radevski, "Stable Gastric Pentadecapeptide BPC 157 Antagonized Local Anesthetic Effect of Lidocaine", Liječnički vjesnik, vol.141, br. suppl.1, str. 0-0, 2019. [Online]. Dostupno na: https://hrcak.srce.hr/221771. [Citirano: 21.02.2020.]

Sažetak
We documented that stable gastric pentadecapeptide BPC 157 counteracts convulsions induced by concomitant application of atypical neuroleptic, SSRI and NSAID, risperidone, citalopram and metamizole in rats. BPC 157, LD1 not achieved, was implemented as an anti-ulcer peptide in inflammatory bowel disease trials and now in a multiple sclerosis trial. Previously, BPC 157 counteracts consequences of dopamine (D), receptors blockade (neuroleptics-induced catalepsy, prolonged QT intervals, sphincters dysfunction and gastric lesions), much like over-stimulation (amphetamine acute and chronic disturbances; much like Dreceptors supersensitivity (amphetamine after haloperidol)), nigrostriatal lesions (MPTP Parkinsogenic neurotoxin), D-vesicles depletion (reserpine). Similarly, BPC 157 counteracts immobility more than imipramine in depression-models (Porsolt’s and chronic unpredictable stress-open field) and induces 5-HT release in particular brain areas (nigrostriatum) when given peripherally, acute and chronically. Also, BPC 157 counteracts convulsions induced by various convulsants (picrotoxine, strychnine, bicuculline) much like either with insulin or with paracetamol. we applied (mg/kg) risperidone 2.5 mg/kg, citalopram 2.0 mg/kg and metamizole 2.0 intraperitoneally. Medication (mg/kg), given 15 min before, or immediately after, includes BPC 157(0.01; 0,00001) while control rats received an equivolume of saline (5 mL/kg). Thereafter, at 20 minutes after medication risperidone/citalopram/metamizole rats became markedly sedated. Then, after the next 20 minutes they start with tonic-clonic seizures. The seizure period was lasting for the next 3 hours. Contrarily, either of BPC 157 regimens maintained normal behavior in all rats. BPC 157 exhibits also an anticonvulsant capacity, as well as a particular profile, which could in a therapy of neuroleptic, SSRI and NSAID intoxication.

Ključne riječi
BPC, convulsions, rats

Hrčak ID: 221771

URI
https://hrcak.srce.hr/221771

Posjeta: 45 *