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Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157

Tajana Đurašin ; School of Medicine University of Zagreb, Department of Pharmacology
Zoya Jelovečki – Dokić ; School of Medicine University of Zagreb, Department of Pharmacology
Josh Fry ; School of Medicine University of Zagreb, Department of Pharmacology
Helena Žižek ; School of Medicine University of Zagreb, Department of Pharmacology
Pavla Peraić ; School of Medicine University of Zagreb, Department of Pharmacology
Filip Radveski ; School of Medicine University of Zagreb, Department of Pharmacology

Puni tekst: engleski, pdf (67 KB) str. 0-0 preuzimanja: 4* citiraj
APA 6th Edition
Đurašin, T., Jelovečki – Dokić, Z., Fry, J., Žižek, H., Peraić, P. i Radveski, F. (2019). Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157. Liječnički vjesnik, 141 (suppl.1), 0-0. Preuzeto s https://hrcak.srce.hr/222560
MLA 8th Edition
Đurašin, Tajana, et al. "Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157." Liječnički vjesnik, vol. 141, br. suppl.1, 2019, str. 0-0. https://hrcak.srce.hr/222560. Citirano 06.12.2019.
Chicago 17th Edition
Đurašin, Tajana, Zoya Jelovečki – Dokić, Josh Fry, Helena Žižek, Pavla Peraić i Filip Radveski. "Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157." Liječnički vjesnik 141, br. suppl.1 (2019): 0-0. https://hrcak.srce.hr/222560
Harvard
Đurašin, T., et al. (2019). 'Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157', Liječnički vjesnik, 141(suppl.1), str. 0-0. Preuzeto s: https://hrcak.srce.hr/222560 (Datum pristupa: 06.12.2019.)
Vancouver
Đurašin T, Jelovečki – Dokić Z, Fry J, Žižek H, Peraić P, Radveski F. Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157. Liječnički vjesnik [Internet]. 2019 [pristupljeno 06.12.2019.];141(suppl.1):0-0. Dostupno na: https://hrcak.srce.hr/222560
IEEE
T. Đurašin, Z. Jelovečki – Dokić, J. Fry, H. Žižek, P. Peraić i F. Radveski, "Suprahepatic inferior caval vein occlusion induced portal and caval hypertension, aortic hypotension and esophageal bleeding. therapy with pentadecapeptide BPC 157", Liječnički vjesnik, vol.141, br. suppl.1, str. 0-0, 2019. [Online]. Dostupno na: https://hrcak.srce.hr/222560. [Citirano: 06.12.2019.]

Sažetak
Pentadecapeptide BPC 157 is intraduced as therapy in a suprahepatic inferior caval vein (ICV) occlusion 15 min, 24h, 48h after complete ICV ligation. Suprahepatic ICV complications that were counteracted by BPC 157 included esophageal bleeding, severe portal and caval hypertension, and aortal hypotension. Likewise, BPC 157 counteracts the lesions in the whole GI-tract. Medication (BPC 157 (10 μg/kg, 10 ng/kg), or saline (5 ml/kg) (controls)) was applied as an abdominal bath immediately after ICV occlusion. ICV occlusion produced severe esophageal bleeding in all controls, along with microscopy findings. Contrarily, given in ischemic period, BPC 157 counteracts severe esophageal bleeding and maintained grossly intact esophageal mucosa . In rats with ICV occlusion, assessment of portal (PV), caval (ICV) and aortal (AA) pressure showed huge portal hypertension and more caval hypertension, along with mild aortic hypotension (15 min: 68±4 PV, 45±4 ICV, 73±3 AA; 24 h: 56±5 PV, 49±5 ICV, 35±3 AA; 48 h 30±3 PV, 48±5 ICV, 39±3 AA-ligation period). Contrarily, BPC 157 in rats with suprahepatic ICV occlusion markedly counteracted portal and caval hypertension, and arterial hypotension (10 μg/kg bath 15 min: 3±1 PV, 9±1 ICV, 117±5 AA; 24 h: 5±1 PV, 9±1 ICV, 67±5 AA; 48 h: 5±1 PV, 9±1 ICV, 70±6 AA), 10 ng/kg bath produced similar results. BPC 157 therapy successfully counteracts the adverse effects of the suprahepatic ICV occlusion.

Ključne riječi
BPC 157, Hypotension, Hypertension, Esophageal bleeding

Hrčak ID: 222560

URI
https://hrcak.srce.hr/222560

Posjeta: 13 *