hrcak mascot   Srce   HID

Sažetak sa skupa

Pentadecapeptide BPC 157 Counteracts the Adverse Effects of Lithium Overdose in Rats

Filip Radevski ; Department of Pharmacology, School of Medicine, University of Zagreb
Zoya Jelovečki-Dokić ; Department of Pharmacology, School of Medicine, University of Zagreb
Marina Madunić ; Department of Pharmacology, School of Medicine, University of Zagreb
Slaven Gojković ; Department of Pharmacology, School of Medicine, University of Zagreb
Helena Žižek ; Department of Pharmacology, School of Medicine, University of Zagreb
Tajana Đurašin ; Department of Pharmacology, School of Medicine, University of Zagreb
Vilim Dretar ; Department of Pharmacology, School of Medicine, University of Zagreb

Puni tekst: engleski, pdf (71 KB) str. 0-0 preuzimanja: 6* citiraj
APA 6th Edition
Radevski, F., Jelovečki-Dokić, Z., Madunić, M., Gojković, S., Žižek, H., Đurašin, T. i Dretar, V. (2019). Pentadecapeptide BPC 157 Counteracts the Adverse Effects of Lithium Overdose in Rats. Liječnički vjesnik, 141 (suppl.1), 0-0. Preuzeto s https://hrcak.srce.hr/222689
MLA 8th Edition
Radevski, Filip, et al. "Pentadecapeptide BPC 157 Counteracts the Adverse Effects of Lithium Overdose in Rats." Liječnički vjesnik, vol. 141, br. suppl.1, 2019, str. 0-0. https://hrcak.srce.hr/222689. Citirano 14.12.2019.
Chicago 17th Edition
Radevski, Filip, Zoya Jelovečki-Dokić, Marina Madunić, Slaven Gojković, Helena Žižek, Tajana Đurašin i Vilim Dretar. "Pentadecapeptide BPC 157 Counteracts the Adverse Effects of Lithium Overdose in Rats." Liječnički vjesnik 141, br. suppl.1 (2019): 0-0. https://hrcak.srce.hr/222689
Harvard
Radevski, F., et al. (2019). 'Pentadecapeptide BPC 157 Counteracts the Adverse Effects of Lithium Overdose in Rats', Liječnički vjesnik, 141(suppl.1), str. 0-0. Preuzeto s: https://hrcak.srce.hr/222689 (Datum pristupa: 14.12.2019.)
Vancouver
Radevski F, Jelovečki-Dokić Z, Madunić M, Gojković S, Žižek H, Đurašin T i sur. Pentadecapeptide BPC 157 Counteracts the Adverse Effects of Lithium Overdose in Rats. Liječnički vjesnik [Internet]. 2019 [pristupljeno 14.12.2019.];141(suppl.1):0-0. Dostupno na: https://hrcak.srce.hr/222689
IEEE
F. Radevski, et al., "Pentadecapeptide BPC 157 Counteracts the Adverse Effects of Lithium Overdose in Rats", Liječnički vjesnik, vol.141, br. suppl.1, str. 0-0, 2019. [Online]. Dostupno na: https://hrcak.srce.hr/222689. [Citirano: 14.12.2019.]

Sažetak
INTRODUCTION We sought to determine whether stable gastric pentadecapeptide BPC 157 mitigates lithium intoxication in rats. METHODS: Lithium was applied at 500 mg/kg/day, intraperitoneally, once daily throughout 3 subsequent days. Medication used (in mg/kg) for the treatment group includes BPC 157 (0.01; 0.00001), L-NAME (5.0), L-arginine (100.0), applied alone and/or together, while control group rats received an equivolume of saline solution (5 mL/kg). At 20 minutes after drug application, we assessed muscular weakness (score 1-5) during the following 8 minutes. Then, for the next 5 minutes, we recorded an ECG. At 3 hours after that, the brain, the heart, the quadriceps muscle and the diaphragm muscle were used for histopathological analysis. RESULTS Consistently, lithium produced severe intoxication syndrome (muscular weakness and prostration, reduced quadriceps muscle fibers and diaphragm, myocardial infarction, and edema of various brain areas, most prominently in the cerebral cortex). The effects worsening with subsequent applications. L-NAME and L-arginine, given separately, both induced severe aggravation. This aggravation disappeared when L-NAME and L-arginine were given together. Contrarily, when given alone or together with NO-agents, BPC 157 reduced muscular weakness and prostration and muscle damage and mitigated lithium induced myocardial damage. BPC 157 reduced nerve damage and brain edema.
CONCLUSION BPC 157 could be used as therapy for lithium intoxication.

Ključne riječi
BPC, lithium, overdose, rats

Hrčak ID: 222689

URI
https://hrcak.srce.hr/222689

Posjeta: 20 *