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https://doi.org/10.20471/acc.2019.58.02.18

Perioperacijske promjene subpopulacija limfocita u bolesnika operiranih zbog kolorektalnog karcinoma

Mateusz Rubinkiewicz ; 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland
Izabela Siemińska ; Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland
Piotr Małczak ; 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland; Centre for Research, Training and Innovation in Surgery (CERT AIN Surgery), Krakow, Poland
Piotr Major ; 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland; Centre for Research, Training and Innovation in Surgery (CERT AIN Surgery), Krakow, Poland
Jarosław Baran ; Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Kraków, Poland
Andrzej Budzyński ; 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland; Centre for Research, Training and Innovation in Surgery (CERT AIN Surgery), Krakow, Poland
Michał Pędziwiatr   ORCID icon orcid.org/0000-0001-7087-6639 ; 2nd Department of General Surgery, Jagiellonian University Medical College, Krakow, Poland; Centre for Research, Training and Innovation in Surgery (CERT AIN Surgery), Krakow, Poland

Puni tekst: engleski, pdf (668 KB) str. 337-342 preuzimanja: 126* citiraj
APA 6th Edition
Rubinkiewicz, M., Siemińska, I., Małczak, P., Major, P., Baran, J., Budzyński, A. i Pędziwiatr, M. (2019). Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer. Acta clinica Croatica, 58 (2.), 337-342. https://doi.org/10.20471/acc.2019.58.02.18
MLA 8th Edition
Rubinkiewicz, Mateusz, et al. "Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer." Acta clinica Croatica, vol. 58, br. 2., 2019, str. 337-342. https://doi.org/10.20471/acc.2019.58.02.18. Citirano 18.09.2020.
Chicago 17th Edition
Rubinkiewicz, Mateusz, Izabela Siemińska, Piotr Małczak, Piotr Major, Jarosław Baran, Andrzej Budzyński i Michał Pędziwiatr. "Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer." Acta clinica Croatica 58, br. 2. (2019): 337-342. https://doi.org/10.20471/acc.2019.58.02.18
Harvard
Rubinkiewicz, M., et al. (2019). 'Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer', Acta clinica Croatica, 58(2.), str. 337-342. https://doi.org/10.20471/acc.2019.58.02.18
Vancouver
Rubinkiewicz M, Siemińska I, Małczak P, Major P, Baran J, Budzyński A i sur. Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer. Acta clinica Croatica [Internet]. 2019 [pristupljeno 18.09.2020.];58(2.):337-342. https://doi.org/10.20471/acc.2019.58.02.18
IEEE
M. Rubinkiewicz, et al., "Perioperative Changes in Lymphocyte Subpopulations in Patients Undergoing Surgery for Colorectal Cancer", Acta clinica Croatica, vol.58, br. 2., str. 337-342, 2019. [Online]. https://doi.org/10.20471/acc.2019.58.02.18

Sažetak
Kirurški zahvat ima golem učinak na ravnotežu imunog sustava. Međutim, malo se zna o perioperacijskim promjenama u subpopulacijama T regulatornih i Th17 limfocita u bolesnika podvrgnutih resekciji kolorektuma. U istraživanje su bili uključeni bolesnici s resektabilnim karcinomom kolona. Uzorci krvi prikupljeni su dva puta: prije zahvata i dva dana nakon operacije. Uključena je bila i kontrolna skupina sastavljena od mladih i zdravih osoba. Subpopulacije limfocita analizirane su protočnom citometrijom. Istraživane su sljedeće subpopulacije: ukupan broj limfocita, CD4+, CD8+, T regulatorni Foxp3+ (Tregs), Th17 i bijela krvna slika. Utvrđene su značajne razlike u razinama imuno stanica prije i nakon operacije. Snižene razine zabilježene su za CD4+, CD8+, Tregs i ukupni broj limfocita (p=0,002, p=0,01, p=0,008 odnosno p=0,001). Povišenje je zapaženo za bijelu krvnu sliku i Th17 stanice, međutim, Th17 limfociti nisu postigli statističku značajnost (p=0,01 odnosno p=0,5). Zaključujemo da je kirurški zahvat uzrokovao promjene u svim istraživanim subpopulacijama limfocita kod bolesnika podvrgnutih operaciji kolorektalnog karcinoma. Međutim, čini se da je to bio učinak perioperacijske traume. Potrebna su daljnja istraživanja kako bi se ispitao utjecaj kirurškog zahvata na subpopulacije limfocita.

Ključne riječi
Subpopulacije limfocita; T-limfociti, regulacijski; Th17 stanice; Broj limfocita; Kolorektalna kirurgija

Hrčak ID: 224608

URI
https://hrcak.srce.hr/224608

[engleski]

Posjeta: 291 *