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Thrombopoietin receptor agonist romiplostim in refractory thrombocytopenia as a bridging therapy to the second allogeneic stem cell transplantation

Paula Kilić ; University of Zagreb Medical School, Zagreb, Croatia; Division of Hematology, Department of Internal Medicine, University Hospital Center Zagreb
Dražen Pulanić ; University of Zagreb Medical School, Zagreb, Croatia;Division of Hematology, Department of Internal Medicine, University Hospital Center Zagreb

Puni tekst: engleski, pdf (63 KB) str. 0-0 preuzimanja: 11* citiraj
APA 6th Edition
Kilić, P. i Pulanić, D. (2019). Thrombopoietin receptor agonist romiplostim in refractory thrombocytopenia as a bridging therapy to the second allogeneic stem cell transplantation. Liječnički vjesnik, 141 (suppl.1), 0-0. Preuzeto s https://hrcak.srce.hr/225031
MLA 8th Edition
Kilić, Paula i Dražen Pulanić. "Thrombopoietin receptor agonist romiplostim in refractory thrombocytopenia as a bridging therapy to the second allogeneic stem cell transplantation." Liječnički vjesnik, vol. 141, br. suppl.1, 2019, str. 0-0. https://hrcak.srce.hr/225031. Citirano 06.12.2019.
Chicago 17th Edition
Kilić, Paula i Dražen Pulanić. "Thrombopoietin receptor agonist romiplostim in refractory thrombocytopenia as a bridging therapy to the second allogeneic stem cell transplantation." Liječnički vjesnik 141, br. suppl.1 (2019): 0-0. https://hrcak.srce.hr/225031
Harvard
Kilić, P., i Pulanić, D. (2019). 'Thrombopoietin receptor agonist romiplostim in refractory thrombocytopenia as a bridging therapy to the second allogeneic stem cell transplantation', Liječnički vjesnik, 141(suppl.1), str. 0-0. Preuzeto s: https://hrcak.srce.hr/225031 (Datum pristupa: 06.12.2019.)
Vancouver
Kilić P, Pulanić D. Thrombopoietin receptor agonist romiplostim in refractory thrombocytopenia as a bridging therapy to the second allogeneic stem cell transplantation. Liječnički vjesnik [Internet]. 2019 [pristupljeno 06.12.2019.];141(suppl.1):0-0. Dostupno na: https://hrcak.srce.hr/225031
IEEE
P. Kilić i D. Pulanić, "Thrombopoietin receptor agonist romiplostim in refractory thrombocytopenia as a bridging therapy to the second allogeneic stem cell transplantation", Liječnički vjesnik, vol.141, br. suppl.1, str. 0-0, 2019. [Online]. Dostupno na: https://hrcak.srce.hr/225031. [Citirano: 06.12.2019.]

Sažetak
Thrombopoietin (TPO) receptor agonist romiplostim mimic the action of TPO and stimulate the activation, proliferation and maturation of megakaryocytes, resulting in an increase in circulating platelet counts. In this work, we present a patient with a Ph-negative chronic myeloid leukemia (CML) with refractory thrombocytopenia treated with romiplostim as a bridging therapy to the second allogeneic stem cell transplantation (alloSCT). A 56-year old male patient was diagnosed with an atypical Ph-negative CML. One year after the diagnosis he underwent alloSCT from HLA-matched unrelated donor, but had early graft rejection, with severe bleeding diathesis, anemia and thrombocytopenia refractory to transfusion therapy. In addition to daily platelet transfusions (sometimes 2 times per day), he received tranexamic acid and intravenous immunoglobulins. Since the severe thrombocytopenia persisted, romiplostim was introduced as subcutaneous once per week treatment. After two weeks of romiplostim therapy, platelet count increased and the need for platelet transfusions decresed, and he was further followed up in outpatient setting receiving romiplostim as a bridging therapy to his second alloSCT that he received latter. This work describe an unusual use of the TPO receptor agonist as a bridging therapy between two alloSCTs to treat severe refractory thrombocytopenia.

Ključne riječi
TPO receptor agonists, romiplostim, allogeneic stem cell transplantation

Hrčak ID: 225031

URI
https://hrcak.srce.hr/225031

Posjeta: 39 *