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Pregledni rad
https://doi.org/10.2478/aiht-2019-70-3258

An overview of microtubule targeting agents for cancer therapy

Bensu Karahalil ; Department of Toxicology, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Sevgi Yardım-Akaydin ; Department of Biochemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey
Sultan Nacak Baytas ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara, Turkey

Puni tekst: engleski, pdf (678 KB) str. 160-172 preuzimanja: 421* citiraj
APA 6th Edition
Karahalil, B., Yardım-Akaydin, S. i Nacak Baytas, S. (2019). An overview of microtubule targeting agents for cancer therapy. Arhiv za higijenu rada i toksikologiju, 70 (3), 160-172. https://doi.org/10.2478/aiht-2019-70-3258
MLA 8th Edition
Karahalil, Bensu, et al. "An overview of microtubule targeting agents for cancer therapy." Arhiv za higijenu rada i toksikologiju, vol. 70, br. 3, 2019, str. 160-172. https://doi.org/10.2478/aiht-2019-70-3258. Citirano 28.02.2021.
Chicago 17th Edition
Karahalil, Bensu, Sevgi Yardım-Akaydin i Sultan Nacak Baytas. "An overview of microtubule targeting agents for cancer therapy." Arhiv za higijenu rada i toksikologiju 70, br. 3 (2019): 160-172. https://doi.org/10.2478/aiht-2019-70-3258
Harvard
Karahalil, B., Yardım-Akaydin, S., i Nacak Baytas, S. (2019). 'An overview of microtubule targeting agents for cancer therapy', Arhiv za higijenu rada i toksikologiju, 70(3), str. 160-172. https://doi.org/10.2478/aiht-2019-70-3258
Vancouver
Karahalil B, Yardım-Akaydin S, Nacak Baytas S. An overview of microtubule targeting agents for cancer therapy. Arh Hig Rada Toksikol. [Internet]. 2019 [pristupljeno 28.02.2021.];70(3):160-172. https://doi.org/10.2478/aiht-2019-70-3258
IEEE
B. Karahalil, S. Yardım-Akaydin i S. Nacak Baytas, "An overview of microtubule targeting agents for cancer therapy", Arhiv za higijenu rada i toksikologiju, vol.70, br. 3, str. 160-172, 2019. [Online]. https://doi.org/10.2478/aiht-2019-70-3258

Sažetak
The entire world is looking for effective cancer therapies whose benefits would outweigh their toxicity. One way to reduce
resistance to chemotherapy and its adverse effects is the so called targeted therapy, which targets specific molecules
(“molecular targets”) that play a critical role in cancer growth, progression, and metastasis. One such specific target are
microtubules. In this review we address the current knowledge about microtubule-targeting agents or drugs (MTAs/MTDs)
used in cancer therapy from their synthesis to toxicities. Synthetic and natural MTAs exhibit antitumor activity, and
preclinical and clinical studies have shown that their anticancer effectiveness is higher than that of traditional drug
therapies. Furthermore, MTAs involve a lower risk of adverse effects such as neurotoxicity and haemotoxicity. Several
new generation MTAs are currently being evaluated for clinical use. This review brings updated information on the
benefits of MTAs, therapeutic approaches, advantages, and challenges in their research.

Ključne riječi
chemotherapy; MDA; microtubule stabilising agents; microtubule destabilising agents; MSA; MTA

Hrčak ID: 225547

URI
https://hrcak.srce.hr/225547

[hrvatski]

Posjeta: 628 *