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Original scientific paper
https://doi.org/10.5562/cca3531

Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles

Livio Racané ; Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Baruna Filipovića 28a, HR-10000 Zagreb, Croatia
Kristina Butković ; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia
Irena Martin-Kleiner ; Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, P. O. Box 180, HR-10000 Zagreb, Croatia
Marijeta Kralj ; Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička cesta 54, P. O. Box 180, HR-10000 Zagreb, Croatia
Grace Karminski-Zamola ; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia
Marijana Hranjec ; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, HR-10000 Zagreb, Croatia

Fulltext: english, pdf (2 MB) pages 181-189 downloads: 264* cite
APA 6th Edition
Racané, L., Butković, K., Martin-Kleiner, I., Kralj, M., Karminski-Zamola, G. & Hranjec, M. (2019). Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles. Croatica Chemica Acta, 92 (2), 181-189. https://doi.org/10.5562/cca3531
MLA 8th Edition
Racané, Livio, et al. "Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles." Croatica Chemica Acta, vol. 92, no. 2, 2019, pp. 181-189. https://doi.org/10.5562/cca3531. Accessed 14 Apr. 2021.
Chicago 17th Edition
Racané, Livio, Kristina Butković, Irena Martin-Kleiner, Marijeta Kralj, Grace Karminski-Zamola and Marijana Hranjec. "Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles." Croatica Chemica Acta 92, no. 2 (2019): 181-189. https://doi.org/10.5562/cca3531
Harvard
Racané, L., et al. (2019). 'Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles', Croatica Chemica Acta, 92(2), pp. 181-189. https://doi.org/10.5562/cca3531
Vancouver
Racané L, Butković K, Martin-Kleiner I, Kralj M, Karminski-Zamola G, Hranjec M. Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles. Croatica Chemica Acta [Internet]. 2019 [cited 2021 April 14];92(2):181-189. https://doi.org/10.5562/cca3531
IEEE
L. Racané, K. Butković, I. Martin-Kleiner, M. Kralj, G. Karminski-Zamola and M. Hranjec, "Synthesis and Antiproliferative activity in vitro of Amidino Substituted 2-phenylbenzazoles", Croatica Chemica Acta, vol.92, no. 2, pp. 181-189, 2019. [Online]. https://doi.org/10.5562/cca3531

Abstracts
Within this work we describe the synthesis of versatile substituted 2-phenyl benzothiazole 3–10 and 2-phenylbenzimidazole 12–19 derivatives bearing amidino groups. Furthermore, the synthesized compounds were explored for their antiproliferative activity in vitro on three cancer cell lines. Tested compounds showed moderate to strong antiproliferative activity. Furthermore, the type of the attached amidino group on benzazole nuclei has the significant impact on the antiproliferative activity only within benzimidazole derivatives with 2-imidazolinyl substituted derivatives being more active in comparison to amidino substituted analogues. All obtained results revealed that this type of benzothiazole derivatives have a great potential for further optimization and development of more efficient potential antiproliferative agents.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords
amidines; benzimidazoles; benzothiazoles; antiproliferative activity in vitro

Hrčak ID: 227007

URI
https://hrcak.srce.hr/227007

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