Stručni rad
https://doi.org/10.5281/zenodo.3517763
Surgical treatment of perihilar cholangiocarcinoma: 10-year experience at a single institution
Ivan Romić
; Klinika za kirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Igor Petrović
; Medicinski fakultet Sveučilišta u Zagrebu i Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Ante Zvonimir Golem
; Klinika za kirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Emil Kinda
; Medicinski fakultet Sveučilišta u Zagrebu i Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Tihomir Kekez
; Medicinski fakultet Sveučilišta u Zagrebu i Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Goran Augustin
; Medicinski fakultet Sveučilišta u Zagrebu i Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Hrvoje Silovski
; Medicinski fakultet Sveučilišta u Zagrebu i Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Tomislav Bruketa
; Klinika za kirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Trpimir Morić
; Klinika za kirurgiju, Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Željko Jelinčić
; Medicinski fakultet Sveučilišta u Zagrebu i Klinički bolnički centar Zagreb, Zagreb, Hrvatska
Sažetak
Background: Our study evaluates surgical outcomes of patients treated for perihilar cholangiocarcinoma in a single institution and demonstrates postoperative (90 days) morbidity and mortality rates and potential prognostic factors associated with complications.
Methods: Medical records of all patients with a diagnosis of perihilar cholangiocarcinoma (pCC) between 2007 and 2017 who underwent a surgical procedure at the University hospital centre Zagreb, were retrospectively evaluated. Statistical analysis to determine predictors of postoperative mortality was performed using the Chi-square test and Fisher exact probability test where appropriate.
Results: Out of 52 surgically treated patients, 43 underwent radical and 9 palliative procedures. Hilar resection and hilar resection along with right hepatectomy were the most commonly performed procedures in 34 radically treated patients. Overall morbidity and mortality rates were 46% and 5.7%, respectively. Significantly higher morbidity rate was observed in a group of patient with untreated preoperative jaundice and in those aged 70 and over.
Conclusion: Current guidelines favor extension of radicality in treatment of pCC by performing left or right hepatectomy in addition to hilar resection. This may increase R0 resection rates and prolong disease free survival. Our experience shows similar mortality/morbidity rates as reported in other centers and confirms that in selected patients, concomitant hepatectomy for perihilar pCC is a safe and feasible surgical strategy.
Ključne riječi
Perihilar cholangiocarcinoma; surgical outcome; survival; Klatskin tumor
Hrčak ID:
228780
URI
Datum izdavanja:
3.11.2019.
Posjeta: 706 *