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Pregledni rad
https://doi.org/10.2478/aiht-2019-70-3317

Forgotten partners and function regulators of inducible metallothioneins

Mirela Pavić   ORCID icon orcid.org/0000-0003-4554-3247 ; Department of Anatomy, Histology and Embryology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Petra Turčić ; Department of Pharmacology, Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Marija Ljubojević   ORCID icon orcid.org/0000-0001-6333-2908 ; Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia

Puni tekst: engleski, pdf (486 KB) str. 256-263 preuzimanja: 141* citiraj
APA 6th Edition
Pavić, M., Turčić, P. i Ljubojević, M. (2019). Forgotten partners and function regulators of inducible metallothioneins. Arhiv za higijenu rada i toksikologiju, 70 (4), 256-263. https://doi.org/10.2478/aiht-2019-70-3317
MLA 8th Edition
Pavić, Mirela, et al. "Forgotten partners and function regulators of inducible metallothioneins." Arhiv za higijenu rada i toksikologiju, vol. 70, br. 4, 2019, str. 256-263. https://doi.org/10.2478/aiht-2019-70-3317. Citirano 17.09.2021.
Chicago 17th Edition
Pavić, Mirela, Petra Turčić i Marija Ljubojević. "Forgotten partners and function regulators of inducible metallothioneins." Arhiv za higijenu rada i toksikologiju 70, br. 4 (2019): 256-263. https://doi.org/10.2478/aiht-2019-70-3317
Harvard
Pavić, M., Turčić, P., i Ljubojević, M. (2019). 'Forgotten partners and function regulators of inducible metallothioneins', Arhiv za higijenu rada i toksikologiju, 70(4), str. 256-263. https://doi.org/10.2478/aiht-2019-70-3317
Vancouver
Pavić M, Turčić P, Ljubojević M. Forgotten partners and function regulators of inducible metallothioneins. Arh Hig Rada Toksikol. [Internet]. 2019 [pristupljeno 17.09.2021.];70(4):256-263. https://doi.org/10.2478/aiht-2019-70-3317
IEEE
M. Pavić, P. Turčić i M. Ljubojević, "Forgotten partners and function regulators of inducible metallothioneins", Arhiv za higijenu rada i toksikologiju, vol.70, br. 4, str. 256-263, 2019. [Online]. https://doi.org/10.2478/aiht-2019-70-3317

Sažetak
Metallothioneins are peculiar cysteine rich, heat resistant, small cellular plasma proteins expressed through almost all life forms. The currently established biological functions of metallothioneins are the homeostasis of essential metals and protection against toxic transitional metals (TM) alongside defence from oxidative stress by direct scavenging of reactive oxygen and nitrogen species (ROS and RNS). In mammals, among the four main evolutionary conserved forms, only the ubiquitously expressed metallothionein 1 and 2 (here abbreviated as MT) are inducible by TM, oxidative stress, glucocorticoids and starvation among various other stimuli. However, more than sixty years after being discovered, metallothioneins still bear unresolved issues about their possible physiological function and regulation. The biological function of MTs has still not been associated with the in vitro-demonstrated capacity of MT interaction with cellular molecules glutathione (GSH) or adenosine triphosphate (ATP), or with the possibility of direct iron-MT binding in the reducing intracellular environment of some organelles, e.g. lysosomes. Iron as the most abundant cellular TM is also one of the main physiological sources of ROS. Moreover, iron exhibits strain, sex and age differences that reflected ROS generation and MT induction in (patho)physiology and toxicology studies. A recent study showed that iron sex differences follows expression of both ferritin and MT leading to wide implications from essential TM interconnectivity to aging. This review places emphasis on biochemically proven but physiologically ignored interactions of MT with iron to stimulate advanced research for establishing a wide frame of the biological roles of MTs important for health and longevity.

Ključne riječi
adenosine triphosphate; aging; copper; ferritin; glutathione; iron; oxidative stress; sex differences; steroid hormones; transition metals; zinc

Hrčak ID: 229297

URI
https://hrcak.srce.hr/229297

[hrvatski]

Posjeta: 393 *