Izvorni znanstveni članak

https://doi.org/10.46419/vs.51.1.3

Monitoring of pharmacologically active substances in milk in the European Union

Nina Bilandžić ; Hrvatski veterinarski institut, Zagreb, Hrvatska
Ivana Varenina ; Hrvatski veterinarski institut, Zagreb, Hrvatska
Božica Solomun Kolanović ; Hrvatski veterinarski institut, Zagreb, Hrvatska
Đurđica Božić Luburić ; Hrvatski veterinarski institut, Zagreb, Hrvatska
Ines Varga ; Hrvatski veterinarski institut, Zagreb, Hrvatska

Sažetak

The production of safe, high quality milk is a key aspect of public health in the European Union (EU). Frequent use of pharmacologically active substances in clinical practice on cattle farms results in the appearance of their residues in a variety of food products, including milk. The most commonly used drugs in the dairy industry are the antibiotics tetracyclines and beta-lactams, used against the pathogenic agents of mastitis. The use of veterinary medicines must be carefully optimized to protect consumers from potential adverse toxic effects. Another major problem is the development of resistance in the consumer that causes the failure of antibiotic therapies, especially against dangerous pathogenic strains of microorganisms. Today, most EU Member States are increasing milk production. The largest milk producers in the EU are Germany, France and the United Kingdom, while over the past 3 years, milk production has been declining in Croatia. EU Member States are seeking to control residues of pharmacologically active substances in milk using selective, sensitive and precise analytical methods. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is the most commonly used instrumental analytical technique for the determination of residues of these substances
in milk. Today, multi-methods have been developed using LC-MS/MS that allow for the identification of 160 or more compounds. In order to protect consumer health, EU Member States carry out controls on pharmacologically active substances in milk as part of their national residue monitoring plans (NRMP). The control of pharmacologically active substances is based on the defined maximum residue levels of those substances (MRL). The European Food Safety Authority (EFSA) collects control data from all EU Member States analysed under the NRMP and produces a joint report each year. Within the NRMP plans of EU Member States, non-compliant results of 0.115%, 0.128% and 0.304% were found for pharmacologically active substances in 2015, 2016 and 2017, respectively. Most of the non-compliant results pertain to the group of antibacterial substances (B1) and non- steroidal anti-inflammatory drugs (B2e). In the antibacterial group, a total of 48.2% of non-compliant beta-lactams were detected in all three years. In 2017, the largest number of non-conforming results was related to non- steroidal anti-inflammatory drugs (54.5%), i.e. in this group 90.5% of non-compliant results were found for salicylic acid.

Ključne riječi

pharmacologically active substances; veterinary drugs; milk; milk control; European Union

Hrčak ID:

233051

URI

https://hrcak.srce.hr/233051

Datum izdavanja:

29.1.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.277 *