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Kratko priopćenje
https://doi.org/10.2478/acph-2021-0006

A cost-effective and sensitive TLC-densitometric identification of meloxicam

WIOLETTA PARYS ; Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland
ALINA PYKA-PAJĄK   ORCID icon orcid.org/0000-0003-2672-7489 ; Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland
MAŁGORZATA DOŁOWY ; Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland

Puni tekst: engleski, pdf (499 KB) str. 143-152 preuzimanja: 61* citiraj
APA 6th Edition
PARYS, W., PYKA-PAJĄK, A. i DOŁOWY, M. (2021). A cost-effective and sensitive TLC-densitometric identification of meloxicam. Acta Pharmaceutica, 71 (1), 143-152. https://doi.org/10.2478/acph-2021-0006
MLA 8th Edition
PARYS, WIOLETTA, et al. "A cost-effective and sensitive TLC-densitometric identification of meloxicam." Acta Pharmaceutica, vol. 71, br. 1, 2021, str. 143-152. https://doi.org/10.2478/acph-2021-0006. Citirano 29.11.2020.
Chicago 17th Edition
PARYS, WIOLETTA, ALINA PYKA-PAJĄK i MAŁGORZATA DOŁOWY. "A cost-effective and sensitive TLC-densitometric identification of meloxicam." Acta Pharmaceutica 71, br. 1 (2021): 143-152. https://doi.org/10.2478/acph-2021-0006
Harvard
PARYS, W., PYKA-PAJĄK, A., i DOŁOWY, M. (2021). 'A cost-effective and sensitive TLC-densitometric identification of meloxicam', Acta Pharmaceutica, 71(1), str. 143-152. https://doi.org/10.2478/acph-2021-0006
Vancouver
PARYS W, PYKA-PAJĄK A, DOŁOWY M. A cost-effective and sensitive TLC-densitometric identification of meloxicam. Acta Pharm. [Internet]. 2021 [pristupljeno 29.11.2020.];71(1):143-152. https://doi.org/10.2478/acph-2021-0006
IEEE
W. PARYS, A. PYKA-PAJĄK i M. DOŁOWY, "A cost-effective and sensitive TLC-densitometric identification of meloxicam", Acta Pharmaceutica, vol.71, br. 1, str. 143-152, 2021. [Online]. https://doi.org/10.2478/acph-2021-0006

Sažetak
The influence of different chromatographic conditions and the process of spot visualization on determining the limit of detection as well as quantification (LOD and LOQ) of meloxicam by TLC-densitometric technique was estimated. Of all chromatographic conditions tested, the lowest limiting values, thus the best sensitivity, in the NP-TLC system was achieved on silica gel 60F254 and neutral aluminum oxide plates developed with the mobile phase consisting of ethyl acetate/toluene/n-butylamine (2:2:1, V/V/V). In the case of the RP-TLC method, a mixture of methanol/water (8:2, V/V) enabled densitometric detection of meloxicam at the lowest concentration level on RP-8F254 and RP-18F254 plates. Additionally, the smallest LOD value of meloxicam ensured crystalline violet and gentian violet as visualization agents on silica gel 60F254 and neutral aluminum oxide 150F254 plates, resp. Comparison of the densitometrically obtained spectra of meloxicam drug and its standard after the use of appropriate visualization agents could be a good and cheap alternative tool for the identification of meloxicam as an active pharmaceutical ingredient.

Ključne riječi
meloxicam; TLC-densitometry; identification; sensitivity; visualization agents

Hrčak ID: 236191

URI
https://hrcak.srce.hr/236191

Posjeta: 128 *