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Pregledni rad
https://doi.org/10.2478/aiht-2020-71-3366

Ferroptosis: regulated cell death

Ivana Čepelak ; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Slavica Dodig ; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medical Biochemistry and Haematology, Zagreb, Croatia
Daniela Čepelak Dodig ; Croatian Institute of Public Health, Department of Toxicology, Zagreb, Croatia

Puni tekst: engleski, pdf (320 KB) str. 99-109 preuzimanja: 108* citiraj
APA 6th Edition
Čepelak, I., Dodig, S. i Čepelak Dodig, D. (2020). Ferroptosis: regulated cell death. Arhiv za higijenu rada i toksikologiju, 71 (2), 99-109. https://doi.org/10.2478/aiht-2020-71-3366
MLA 8th Edition
Čepelak, Ivana, et al. "Ferroptosis: regulated cell death." Arhiv za higijenu rada i toksikologiju, vol. 71, br. 2, 2020, str. 99-109. https://doi.org/10.2478/aiht-2020-71-3366. Citirano 03.12.2020.
Chicago 17th Edition
Čepelak, Ivana, Slavica Dodig i Daniela Čepelak Dodig. "Ferroptosis: regulated cell death." Arhiv za higijenu rada i toksikologiju 71, br. 2 (2020): 99-109. https://doi.org/10.2478/aiht-2020-71-3366
Harvard
Čepelak, I., Dodig, S., i Čepelak Dodig, D. (2020). 'Ferroptosis: regulated cell death', Arhiv za higijenu rada i toksikologiju, 71(2), str. 99-109. https://doi.org/10.2478/aiht-2020-71-3366
Vancouver
Čepelak I, Dodig S, Čepelak Dodig D. Ferroptosis: regulated cell death. Arh Hig Rada Toksikol. [Internet]. 2020 [pristupljeno 03.12.2020.];71(2):99-109. https://doi.org/10.2478/aiht-2020-71-3366
IEEE
I. Čepelak, S. Dodig i D. Čepelak Dodig, "Ferroptosis: regulated cell death", Arhiv za higijenu rada i toksikologiju, vol.71, br. 2, str. 99-109, 2020. [Online]. https://doi.org/10.2478/aiht-2020-71-3366

Sažetak
Ferroptosis is a recently identified form of regulated cell death that differs from other known forms of cell death morphologically, biochemically, and genetically. The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity. Ferroptosis has increasingly been associated with neurodegenerative diseases, carcinogenesis, stroke, intracerebral haemorrhage, traumatic brain injury, and ischemia-reperfusion injury. It has also shown a significant therapeutic potential in the treatment of cancer and other diseases. This review summarises current knowledge about and the mechanisms that regulate ferroptosis.

Ključne riječi
glutathione peroxidase 4; iron; lipid peroxidation; reactive oxygen species; system XcČepelak

Hrčak ID: 239231

URI
https://hrcak.srce.hr/239231

[hrvatski]

Posjeta: 254 *