Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2019.60.20
Simple predictors of the reoccurrence of severe febrile neutropenia episode: a singlecenter retrospective cohort study in pediatric patients with malignant diseases
Silvije Šegulja
; Department of Pediatrics, Hospital Thalassotherapia Crikvenica,Thalassotherapia Crikvenica, Croatia
Alen Ružić
; Department of Internal Medicine, Clinical Hospital Center Rijeka, Rijeka, Croatia
Dora Dujmić
; Lawrence University, Appleton, WI, United States
Ksenija Baždarić
; Department of Medical Informatics, University of Rijeka, Faculty of Medicine, Rijeka, Croatia
Jelena Roganović
; Department of Pediatrics, Clinical Hospital Center Rijeka, Rijeka, Croatia
Sažetak
Aim To identify the risk factors of a repeated episode of severe
febrile neutropenia (FN) and to build an accurate and
easy-to-use predictive model.
Methods This single-center retrospective cohort study
conducted at the Clinical Hospital Center Children’s Hospital
Rijeka from January 1, 2008 to December 31, 2016
included pediatric patients with malignant diseases who
experienced at least one FN episode. The association of
the second severe FN episode appearance with relevant
clinical and laboratory data was analyzed by logistic regression Results Out of 45 patients with one FN episode, 25 (56%)
had severe FN and 11 (24%) had repeated severe FNs. Significant
predictors of a repeated severe FN episode were
the first FN episode duration of 9 or more days and red
blood cells ≤3.0 × 1012/L. The predictive model constructed
by crossing these two indicators had the accuracy of
87% (95% confidence interval [CI] 73%-94%), sensitivity
of 82% (95% CI 53%-97%), and specificity of 88% (95% CI
79%-93%).
Conclusion The first FN episode duration and anemia are
significantly associated with the risk for severe FN re-occurrence.
These factors may be useful in the identification of
children with cancer who are at high risk for adverse outcome
at any future fever onset and may benefit from early
intensive treatment.
Ključne riječi
Hrčak ID:
239730
URI
Datum izdavanja:
15.2.2019.
Posjeta: 727 *