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https://doi.org/10.3325/cmj.2019.60.333

Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study

Marija Bakula   ORCID icon orcid.org/0000-0002-0176-362X ; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia
Nada Čikeš ; Center for Translational and Clinical Research, University ofZagreb School of Medicine andUniversity Hospital Center Zagreb, Zagreb, Croatia
Branimir Anić ; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia

Puni tekst: engleski, pdf (1 MB) str. 333-344 preuzimanja: 23* citiraj
APA 6th Edition
Bakula, M., Čikeš, N. i Anić, B. (2019). Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study. Croatian medical journal, 60 (4), 333-344. https://doi.org/10.3325/cmj.2019.60.333
MLA 8th Edition
Bakula, Marija, et al. "Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study." Croatian medical journal, vol. 60, br. 4, 2019, str. 333-344. https://doi.org/10.3325/cmj.2019.60.333. Citirano 02.12.2020.
Chicago 17th Edition
Bakula, Marija, Nada Čikeš i Branimir Anić. "Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study." Croatian medical journal 60, br. 4 (2019): 333-344. https://doi.org/10.3325/cmj.2019.60.333
Harvard
Bakula, M., Čikeš, N., i Anić, B. (2019). 'Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study', Croatian medical journal, 60(4), str. 333-344. https://doi.org/10.3325/cmj.2019.60.333
Vancouver
Bakula M, Čikeš N, Anić B. Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study. Croat Med J. [Internet]. 2019 [pristupljeno 02.12.2020.];60(4):333-344. https://doi.org/10.3325/cmj.2019.60.333
IEEE
M. Bakula, N. Čikeš i B. Anić, "Validation of the new classification criteria for systemic lupus erythematosus on a patient cohort from a national referral center: a retrospective study", Croatian medical journal, vol.60, br. 4, str. 333-344, 2019. [Online]. https://doi.org/10.3325/cmj.2019.60.333

Sažetak
Aim To validate Systemic Lupus International Collaborating
Clinics (SLICC)-12 and American College of Rheumatology
(ACR)-97 classification criteria on a patient cohort from
the University Hospital Center Zagreb.
Methods This retrospective study, conducted from 2014
to 2016, involved 308 patients with systemic lupus erythematosus
(SLE) (n = 146) and SLE-allied conditions (n = 162).
Patients’ medical charts were evaluated by an expert rheumatologist
to confirm the clinical diagnosis, regardless of
the number of the ACR-97 criteria met. Overall sensitivity
and specificity, as well as the sensitivity and specificity according
to disease duration, were compared between ACR-
97 and SLICC-12 classifications. Predictive value for SLE for
both classifications was assessed using logistic regression
and receiver operating characteristic (ROC) curves. Results The SLICC-12 criteria had significantly higher sensitivity
in early disase, which increased with disease duration.
The ACR-97 criteria had higher specificity. The specificity
of the SLICC-12 criteria was low and decreased with
disease duration. Regression analysis demonstrated the
superiority of the SLICC-12 classification criteria over the
ACR-97 criteria, with areas under the ROC curve of 0.801
and 0.780, respectively.
Conclusion Although the SLICC-12 criteria were superior
to the ACR-97 and were more sensitive for diagnosing
early SLE, their specificity in our population was too low.
The sensitivity of the SLICC-12 classification is increased by
better defined clinical features within each criterion. Our
results contribute to the current initiative for developing
new criteria for SLE.

Hrčak ID: 240099

URI
https://hrcak.srce.hr/240099

Posjeta: 51 *