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https://doi.org/10.46419/vs.51.5.7

History of tuberculosis - from tuberculin to antituberculotics (Part II)

Željko Cvetnić ; Croatian Veterinary Institute - Regional Department Križevci, Križevci
Željko Dugac ; Department of History and Philosophy of Science, Croatian Academy of Sciences and Arts, Croatia

Puni tekst: hrvatski, pdf (374 KB) str. 0-0 preuzimanja: 47* citiraj
APA 6th Edition
Cvetnić, Ž. i Dugac, Ž. (2020). Povijest tuberkuloze - od tuberkulina do antituberkulotika (II. dio). Veterinarska stanica, 51 (5), 0-0. https://doi.org/10.46419/vs.51.5.7
MLA 8th Edition
Cvetnić, Željko i Željko Dugac. "Povijest tuberkuloze - od tuberkulina do antituberkulotika (II. dio)." Veterinarska stanica, vol. 51, br. 5, 2020, str. 0-0. https://doi.org/10.46419/vs.51.5.7. Citirano 31.10.2020.
Chicago 17th Edition
Cvetnić, Željko i Željko Dugac. "Povijest tuberkuloze - od tuberkulina do antituberkulotika (II. dio)." Veterinarska stanica 51, br. 5 (2020): 0-0. https://doi.org/10.46419/vs.51.5.7
Harvard
Cvetnić, Ž., i Dugac, Ž. (2020). 'Povijest tuberkuloze - od tuberkulina do antituberkulotika (II. dio)', Veterinarska stanica, 51(5), str. 0-0. https://doi.org/10.46419/vs.51.5.7
Vancouver
Cvetnić Ž, Dugac Ž. Povijest tuberkuloze - od tuberkulina do antituberkulotika (II. dio). Veterinarska stanica [Internet]. 2020 [pristupljeno 31.10.2020.];51(5):0-0. https://doi.org/10.46419/vs.51.5.7
IEEE
Ž. Cvetnić i Ž. Dugac, "Povijest tuberkuloze - od tuberkulina do antituberkulotika (II. dio)", Veterinarska stanica, vol.51, br. 5, str. 0-0, 2020. [Online]. https://doi.org/10.46419/vs.51.5.7

Sažetak
The discovery of the causative agent of tuberculosis Mycobacterium tuberculosis in 1882 was one of the most important events in medical history, especially bacteriology. Since the causes of tuberculosis were not treatable, there were various attempts to help tuberculosis patients. The German physician Hermann Brehmer built the first sanatorium in Görbersdorf, Germany in 1857 to treat tuberculosis patients. One of the founders of the tuberculosis sanatorium in Croatia (Brestovac on Mt. Sljeme) was Dr. Milivoj Dezman. In 1888, Italian doctor Carlo Forlanini performed the first artificial pneumothorax, causing lung collapse and filling the pleural cavities with nitrogen. Tuberculosis surgical treatments were developed and applied until the 1940s. A significant step forward in diagnosing tuberculosis was the discovery of the X-ray in 1895. Robert Koch discovered tuberculin in 1890, which initially was not a medicament but a diagnostic agent. Albert Calmette and his aide, Camille Guérin, achieved great progress in combatting tuberculosis. They succeeded in developing BCG (Bacillus Calmette- Guérin), a vaccine against tuberculosis first administered at a Paris hospital in 1921. In early 1943, Jörgen Eric Lehmann discovered paraminosalicylic acid (PAS), and in 1944, biochemist Selman Abraham Waksman and his associates developed the antibiotic streptomycin, the first medicine to treat tuberculosis. In the mid-1950s, an isoniazid was added to the combination of streptomycin and PAS, while and many other medicines such as pyrazinamides were subsequently discovered (1954). Ethambutol and rifampicin were introduced to the treatment protocol in 1961 and 1963, respectively. A new era of treatment for tuberculosis has begun and many tuberculosis sanatoriums have since been closed. The new treatment of tuberculosis in the Western world, together with BCG vaccination, reduced tuberculosis deaths by nearly 90% and shortened the duration of therapy from two years to six months. With this, the history of tuberculosis control and treatment has entered a new chapter.

Ključne riječi
sanatorium; tuberculin; BCG; paraaminosalicylic acid (PAS); streptomycin

Hrčak ID: 241056

URI
https://hrcak.srce.hr/241056

[hrvatski]

Posjeta: 107 *