Izvorni znanstveni članak

https://doi.org/10.20471/acc.2020.59.01.15

The Impact of Positive Anti-HBC Marker on Permanent Deferral of Voluntary Blood Donors in Eastern Croatia and Estimation of Occult Hepatitis B Virus Infection Rate

Marko Samardžija ; Nord-Trøndelag Hospital Trust, Namsos Hospital, Department of Internal Medicine, Namsos, Norway
Domagoj Drenjančević orcid.org/0000-0002-7348-6895 ; Osijek University Hospital Centre, Department of Transfusion Medicine, Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Manuela Miletić ; Croatian Institute of Transfusion Medicine, Zagreb, Croatia
Blaženka Slavulj ; Osijek University Hospital Centre, Department of Transfusion Medicine, Osijek, Croatia
Irena Jukić ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Croatian Institute of Transfusion Medicine, Zagreb, Croatia
Lada Zibar ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Merkur University Hospital, Department of Internal Medicine, Zagreb, Croatia
Silvio Mihaljević ; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Osijek University Hospital Centre, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Osijek, Croatia
Marina Ferenac Kiš ; Osijek University Hospital Centre, Department of Transfusion Medicine, Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Marina Samardžija ; Osijek University Hospital Centre, Department of Transfusion Medicine, Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

Sažetak

Recently an increase has been reported in the number of HBV transmissions from anti-HBc positive blood donors that were repeatedly negative in HBsAg and nucleic acid testing using the most sensitive tests available. The aim of the study was to show the effect of anti-HBc antibody testing performed in 2006 on permanent deferral of voluntary blood donors (VBDs), and to estimate occult hepatitis B infection (OBI) rate in this population after the introduction of mandatory molecular
testing in the 2013-2016 period. More than 30,000 blood donations collected during the 2005-2007 period and more than 14,000 VBDs having donated blood during the 2013-2016 period after the introduction of molecular testing from eastern Croatia were included in the study. Serologic testing was performed with HBsAg assay throughout the study period, and anti-HBc assay was only
performed in 2006. As part of the confirmatory algorithm testing, all HBsAg positive and unclear results were tested with molecular tests. Anti-HBc prevalence among VBDs in 2006 was 1.5%, with a rate of 1:197, whereas HBsAg prevalence was stable from 2005 to 2007 (0.04%, 0.1% and 0.1%, respectively). The calculated OBI rate from 2013 to 2016 was 1:30,250. Ten of 161 (12.4%) VBDs had serologic anti-HBc-only pattern. Anti-HBc testing in 2006 resulted in statistically more deferrals of VBDs compared to 2005 and 2007, and to the rest of Republic of Croatia. The strategy of universal anti-HBc testing of VBDs in addition to the existing HBsAg and molecular screening could be an
additional measure to prevent HBV transmission by blood and blood components.

Ključne riječi

Blood donors; Hepatitis B; Hepatitis B virus; Hepatitis B surface antigen; Croatia

Hrčak ID:

242298

URI

https://hrcak.srce.hr/242298

Datum izdavanja:

1.3.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.454 *