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Review article
https://doi.org/10.2478/acph-2022-0008

Application of neurotoxin- and pesticide-induced animal models of Parkinson's disease in the evaluation of new drug delivery systems

YAQUELYN CASANOVA ; Department of Pharmaceutics and Food Technology, School of Pharmacy, Universidad Complutense de Madrid, Madrid, Spain
SOFIA NEGRO ; Department of Pharmaceutics and Food Technology, School of Pharmacy, Universidad Complutense de Madrid, Madrid, Spain
EMILIA BARCIA ; Department of Pharmaceutics and Food Technology, School of Pharmacy, Universidad Complutense de Madrid, Madrid, Spain

Fulltext: english, pdf (485 KB) pages 35-58 downloads: 90* cite
APA 6th Edition
CASANOVA, Y., NEGRO, S. & BARCIA, E. (2022). Application of neurotoxin- and pesticide-induced animal models of Parkinson's disease in the evaluation of new drug delivery systems. Acta Pharmaceutica, 72 (1), 35-58. https://doi.org/10.2478/acph-2022-0008
MLA 8th Edition
CASANOVA, YAQUELYN, et al. "Application of neurotoxin- and pesticide-induced animal models of Parkinson's disease in the evaluation of new drug delivery systems." Acta Pharmaceutica, vol. 72, no. 1, 2022, pp. 35-58. https://doi.org/10.2478/acph-2022-0008. Accessed 7 Dec. 2021.
Chicago 17th Edition
CASANOVA, YAQUELYN, SOFIA NEGRO and EMILIA BARCIA. "Application of neurotoxin- and pesticide-induced animal models of Parkinson's disease in the evaluation of new drug delivery systems." Acta Pharmaceutica 72, no. 1 (2022): 35-58. https://doi.org/10.2478/acph-2022-0008
Harvard
CASANOVA, Y., NEGRO, S., and BARCIA, E. (2022). 'Application of neurotoxin- and pesticide-induced animal models of Parkinson's disease in the evaluation of new drug delivery systems', Acta Pharmaceutica, 72(1), pp. 35-58. https://doi.org/10.2478/acph-2022-0008
Vancouver
CASANOVA Y, NEGRO S, BARCIA E. Application of neurotoxin- and pesticide-induced animal models of Parkinson's disease in the evaluation of new drug delivery systems. Acta Pharm. [Internet]. 2022 [cited 2021 December 07];72(1):35-58. https://doi.org/10.2478/acph-2022-0008
IEEE
Y. CASANOVA, S. NEGRO and E. BARCIA, "Application of neurotoxin- and pesticide-induced animal models of Parkinson's disease in the evaluation of new drug delivery systems", Acta Pharmaceutica, vol.72, no. 1, pp. 35-58, 2022. [Online]. https://doi.org/10.2478/acph-2022-0008

Abstracts
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral dopaminergic neurons and a decrease in the dopamine contents of the caudate-putamen structures. To this date, there is no cure for the disease and available treatments are aimed at controlling the symptoms. Therefore, there is an unmet need for new treatments for PD. In the past decades, animal models of PD have been proven to be valuable tools in elucidating the nature of the pathogenic processes involved in the disease, and in designing new pharmacological approaches. Here, we review the use of neurotoxin-induced and pesticide-induced animal models of PD, specifically those induced by rotenone, paraquat, maneb, MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and 6-OHDA (6-hydroxydopamine), and their application in the development of new drug delivery systems for PD.

Keywords
Parkinson's disease; rotenone; paraquat; maneb; MPTP; 6-OHDA; animal model; controlled drug delivery

Hrčak ID: 253965

URI
https://hrcak.srce.hr/253965

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