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Kratko priopćenje
https://doi.org/10.2478/acph-2022-0002

Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons

JINGJING TAN ; Department of Anesthesia and Perioperative Medicine, Shanghai Fourth People's Hospital, Affiliated to Tongji University, Shanghai 200081 China
MANOJ KUMAR YADAV ; Department of Pharmacology, Swift School of Pharmacy, Ghaggar Sarai, Rajpura (Patiala) Punjab – 140401, India
SUSHMA DEVI   ORCID icon orcid.org/0000-0002-4449-9072 ; Department of Pharmacology, Swift School of Pharmacy, Ghaggar Sarai, Rajpura (Patiala) Punjab – 140401, India
MANISH KUMAR   ORCID icon orcid.org/0000-0001-6697-544X ; Department of Pharmacology, Swift School of Pharmacy, Ghaggar Sarai, Rajpura (Patiala) Punjab – 140401, India; Chitkara College of Pharmacy, Chitkara University, Rajpura (Patiala) Punjab – 140401, India

Puni tekst: engleski, pdf (2 MB) str. 123-134 preuzimanja: 70* citiraj
APA 6th Edition
TAN, J., KUMAR YADAV, M., DEVI, S. i KUMAR, M. (2022). Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons. Acta Pharmaceutica, 72 (1), 123-134. https://doi.org/10.2478/acph-2022-0002
MLA 8th Edition
TAN, JINGJING, et al. "Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons." Acta Pharmaceutica, vol. 72, br. 1, 2022, str. 123-134. https://doi.org/10.2478/acph-2022-0002. Citirano 08.12.2021.
Chicago 17th Edition
TAN, JINGJING, MANOJ KUMAR YADAV, SUSHMA DEVI i MANISH KUMAR. "Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons." Acta Pharmaceutica 72, br. 1 (2022): 123-134. https://doi.org/10.2478/acph-2022-0002
Harvard
TAN, J., et al. (2022). 'Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons', Acta Pharmaceutica, 72(1), str. 123-134. https://doi.org/10.2478/acph-2022-0002
Vancouver
TAN J, KUMAR YADAV M, DEVI S, KUMAR M. Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons. Acta Pharm. [Internet]. 2022 [pristupljeno 08.12.2021.];72(1):123-134. https://doi.org/10.2478/acph-2022-0002
IEEE
J. TAN, M. KUMAR YADAV, S. DEVI i M. KUMAR, "Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons", Acta Pharmaceutica, vol.72, br. 1, str. 123-134, 2022. [Online]. https://doi.org/10.2478/acph-2022-0002

Sažetak
In this study, the neuroprotective potential of arbutin (100 µmol L–1) pre-treatment and post-treatment against oxygen/glucose deprivation (OGD) and reoxygenation (R) induced ischemic injury in cultured rat cortical neurons was explored. The OGD (60 min) and reoxygenation (24 h) treatment significantly (p < 0.001) compromised the antioxidant defence in cultured neurons. Subsequently, an increase (p < 0.001) in lipid peroxidation and inflammatory cytokines (tumour necrosis factor-α and nuclear factor kappa-B) declined neuron survival. In pre- and post-condition experiments, treatment with arbutin enhanced both survival (p < 0.01) and integrity (p < 0.05) of cultured neurons. Results showed that arbutin protects (p < 0.05) against peroxidative changes, inflammation, and enhanced the antioxidant activity (e.g., glutathione, superoxide dismutase and catalase) in cultured neurons subjected to OGD/R. It can be inferred that arbutin could protect against ischemic injuries and stroke. The anti-ischemic activity of arbutin can arrest post-stroke damage to the brain.

Ključne riječi
arbutin; cerebral ischemia; inflammation; oxidative stress

Hrčak ID: 253968

URI
https://hrcak.srce.hr/253968

Posjeta: 145 *